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TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050546(CHEMBL3182699)
Affinity DataIC50: 1nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050542(CHEMBL3183497)
Affinity DataIC50: 2nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050547(CHEMBL3182449)
Affinity DataIC50: 2nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458964((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Affinity DataIC50: 2.80nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50312125(3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50312105(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Affinity DataIC50: 4nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050541(CHEMBL3188749)
Affinity DataIC50: 4nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458965((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Affinity DataIC50: 4.20nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458969(US10759794, Example 54)
Affinity DataIC50: 4.30nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458968(US10759794, Example 47)
Affinity DataIC50: 4.90nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050538(CHEMBL3182091)
Affinity DataIC50: 5nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050544(CHEMBL3187764)
Affinity DataIC50: 7nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50123519(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM532166([3-{[2-(5-Chloropyridin-2-yl)imidazo[1,2-a]pyridin...)
Affinity DataIC50: 7.54nMAssay Description:Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50: 7.90nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050503(CHEMBL3187482)
Affinity DataIC50: 9nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM413514(US10414765, Example 17)
Affinity DataIC50: 9.30nMAssay Description:In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458966((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...)
Affinity DataIC50: 9.70nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050534(CHEMBL3183773)
Affinity DataIC50: 10nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050540(CHEMBL3182359)
Affinity DataIC50: 10nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050547(CHEMBL3182449)
Affinity DataIC50: 10nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050545(CHEMBL3186000)
Affinity DataIC50: 11nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050503(CHEMBL3187482)
Affinity DataIC50: 11nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM532051(US11208422, Example 12 | 3-{[2-(4-Chlorophenyl)imi...)
Affinity DataIC50: 11.4nMAssay Description:Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218253(US9284333, 16c)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218442(US9284333, 16hb | US9884860, Example 16hb)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218623(US9284333, 16mb | US9884860, Example 16mb)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM282814(US9884860, Example 16c | 6-((S)-2-Methyl-pyrrolidi...)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218442(US9284333, 16hb | US9884860, Example 16hb)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218623(US9284333, 16mb | US9884860, Example 16mb)
Affinity DataIC50: 13nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM458967(US10759794, Example 39)
Affinity DataIC50: 13.4nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050530(CHEMBL3188857)
Affinity DataIC50: 14nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218341(US9284333, 16cg | US9884860, Example 16cg)
Affinity DataIC50: 15nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218341(US9284333, 16cg | US9884860, Example 16cg)
Affinity DataIC50: 15nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50312105(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Affinity DataIC50: 16nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by QPatch assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50312105(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human TASK1 expressed in CHO cells by Qpatch HT platform based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50312105(2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human TASK-1 expressed in CHO cells assessed as inhibition of channel current at -30mV holding potential incubated for 5 mins by two-el...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM532051(US11208422, Example 12 | 3-{[2-(4-Chlorophenyl)imi...)
Affinity DataIC50: 17.6nMAssay Description:Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM515511((5-Cyclopropyl-1,3-oxazol-4-yl)(5-{[2-(4-isopropyl...)
Affinity DataIC50: 17.9nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM179693(US9127001, 8b | US9598410, Compound 8b)
Affinity DataIC50: 19nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM179693(US9127001, 8b | US9598410, Compound 8b)
Affinity DataIC50: 19nMAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM515509(US11098063, Example 21 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 19.2nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM515512(US11098063, Example 28 | (3-Fluoro-6-methoxypyridi...)
Affinity DataIC50: 20.5nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM532162(US11208422, Example 14 | 3-{[2-(4-Chlorophenyl)imi...)
Affinity DataIC50: 20.6nMAssay Description:Xenopus laevis oocytes were selected as described elsewhere by way of illustration [Decher et al., FEBS Lett. 492, 84-89 (2001)]. Subsequently, the o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218340(US9284333, 16cf | US9884860, Example 16cf)
Affinity DataIC50: 21nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50050433(CHEMBL3186489)
Affinity DataIC50: 21nMAssay Description:Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM218340(US9284333, 16cf | US9884860, Example 16cf)
Affinity DataIC50: 21nMT: 2°CAssay Description:Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM515513(US11098063, Example 29 | (3-Chloro-6-methoxypyridi...)
Affinity DataIC50: 21nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium channel subfamily K member 3(Human)
University of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM515515(US11098063, Example 51)
Affinity DataIC50: 21.7nMAssay Description:Table 1: In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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