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TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652093(US11905244, Compound 112)
Affinity DataIC50: 0.200nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652068(US11905244, Compound 87)
Affinity DataIC50: 0.950nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652092(US11905244, Compound 111)
Affinity DataIC50: 1.60nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652087(US11905244, Compound 106)
Affinity DataIC50: 5.01nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652094(US11905244, Compound 113)
Affinity DataIC50: 5.83nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652096(US11905244, Compound 115)
Affinity DataIC50: 5.84nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652067(US11905244, Compound 86)
Affinity DataIC50: 6.34nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652083(US11905244, Compound 102)
Affinity DataIC50: 9.20nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652047(US11905244, Compound 66)
Affinity DataIC50: 10.5nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652077(US11905244, Compound 96)
Affinity DataIC50: 10.9nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652082(US11905244, Compound 101)
Affinity DataIC50: 11.2nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652043(US11905244, Compound 62)
Affinity DataIC50: 11.3nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652060(US11905244, Compound 79)
Affinity DataIC50: 11.7nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652034(US11905244, Compound 53)
Affinity DataIC50: 13nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652081(US11905244, Compound 100)
Affinity DataIC50: 14.8nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652084(US11905244, Compound 103)
Affinity DataIC50: 15.8nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652080(US11905244, Compound 99)
Affinity DataIC50: 18.2nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141416(US8921364, 67 | US10668051, Compound Example 67)
Affinity DataIC50: 20.4nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141426(US8921364, 84 | US10668051, Compound Example 84)
Affinity DataIC50: 20.8nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652079(US11905244, Compound 98)
Affinity DataIC50: 21.2nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652063(US11905244, Compound 82)
Affinity DataIC50: 22.4nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141438(US8921364, 104 | US10668051, Compound Example 104)
Affinity DataIC50: 23nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652045(US11905244, Compound 64)
Affinity DataIC50: 24.9nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM50204536(CHEMBL3984105)
Affinity DataIC50: 26nMAssay Description:Inhibition of Orai1 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652046(US11905244, Compound 65)
Affinity DataIC50: 30.6nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141428(US8921364, 87 | US10668051, Compound Example 87)
Affinity DataIC50: 32.6nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141421(US8921364, 78 | US10668051, Compound Example 78)
Affinity DataIC50: 34.1nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141424(US8921364, 82 | US10668051, Compound Example 82)
Affinity DataIC50: 35.7nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141396(US8921364, 7 | US10668051, Compound Example 7)
Affinity DataIC50: 36.4nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141444(US8921364, 114 | US10668051, Compound Example 114)
Affinity DataIC50: 37.6nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM152937(US8993612, 20)
Affinity DataIC50: 39.2nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141442(US8921364, 111 | US10668051, Compound Example 111)
Affinity DataIC50: 47.2nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141419(US8921364, 74 | US10668051, Compound Example 74)
Affinity DataIC50: 48nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141418(US8921364, 72 | US10668051, Compound Example 72)
Affinity DataIC50: 48.2nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141425(US8921364, 83 | US10668051, Compound Example 83)
Affinity DataIC50: 48.2nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141441(US8921364, 108 | US10668051, Compound Example 108)
Affinity DataIC50: 50.6nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM152932(US8993612, 6)
Affinity DataIC50: 51.3nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141448(US8921364, 126 | US10668051, Compound Example 126)
Affinity DataIC50: 52.6nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM152936(US8993612, 18)
Affinity DataIC50: 53.4nMT: 2°CAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141439(US8921364, 106 | US10668051, Compound Example 106)
Affinity DataIC50: 60nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141402(US8921364, 28 | US10668051, Compound Example 28)
Affinity DataIC50: 60.3nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652002(US11905244, Compound 21)
Affinity DataIC50: 60.3nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141393(US8921364, 1 | US10668051, Compound Example 1)
Affinity DataIC50: 62.4nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141443(US8921364, 113 | US10668051, Compound Example 113)
Affinity DataIC50: 62.6nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141412(US8921364, 56 | US10668051, Compound Example 56)
Affinity DataIC50: 63.2nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141409(US8921364, 49 | US10668051, Compound Example 49)
Affinity DataIC50: 65.5nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141440(US8921364, 107 | US10668051, Compound Example 107)
Affinity DataIC50: 70.3nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141411(US8921364, 53 | US10668051, Compound Example 53)
Affinity DataIC50: 72nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM141445(US8921364, 122 | US10668051, Compound Example 122)
Affinity DataIC50: 72.1nMAssay Description:Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCalcium release-activated calcium channel protein 1(Human)
The Texas A&M University System

US Patent
LigandPNGBDBM652044(US11905244, Compound 63)
Affinity DataIC50: 74.4nMAssay Description:Using the GFP-NFAT translocation assay method, the inhibitory activity of the selected compounds at 200 μM concentration was evaluated. As demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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