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Report error Found 4038 of ic50 data for polymerid = 6750,50000977,50001400
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen ) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 0.200nMpH: 7.5 T: 2°CAssay Description:Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM249396(US9434697, 108 | US9730931, Compound 108 | US10537...)
Affinity DataIC50: 0.200nMAssay Description:Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM50559106(CHEMBL4786195)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM209349(US9266883, 148)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM681762(US20240199625, Compound 5)
Affinity DataIC50: 0.300nMAssay Description:Compound preparation: Add 45 μL of DMSO to 5 μL of stock solution at a concentration of 10 mM to prepare the solution LY2874455 at 1000 M; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM50634938(CHEMBL5523644)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559126(CHEMBL4796410)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50554188(CHEMBL4744686)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal 6x-His tagged FGFR4 catalytic domain (445-753 residues) (unknown origin) using IYGEFKKK substrate and [gamma-32P]-ATP incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM604879(N-(5-Cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-...)
Affinity DataIC50: 0.400nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM50634964(CHEMBL5557389)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM523849(US11136320, Compound 8)
Affinity DataIC50: 0.420nMAssay Description:The FGFR4 kinase inhibition of compounds was tested by using mobility shift assay in this experiment, and the rate of FGFR4 kinase inhibition of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM50634942(CHEMBL5505760)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50593531(Asp 5878 | Asp-5878 | Asp5878 | ASP-5878 | ASP5878)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) by mobility assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.5nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM161392(US9108973, 5 | US10124003, Ex. Compound 5 | US1089...)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal 6His-tagged FGFR4 (unknown orgin) (445 to 753 residues) expressed in Rosetta (NEB) cells using poly(Glu, Tyr) 4:1 peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50644192(CHEMBL5570033)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50644193(CHEMBL5571683)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50575048(CHEMBL4866267)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of N-terminal GST fusion tagged human FGFR4 cytoplasmic domain (460 to 802 end residues) expressed in baculovirus expression system preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634958(CHEMBL5532250)
Affinity DataIC50: 0.570nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559105(CHEMBL4754106)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM604880(N-(5-Cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-...)
Affinity DataIC50: 0.600nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634953(CHEMBL5523440)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM681767(US20240199625, Compound 15)
Affinity DataIC50: 0.630nMAssay Description:Compound preparation: Add 45 μL of DMSO to 5 μL of stock solution at a concentration of 10 mM to prepare the solution LY2874455 at 1000 M; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634963(CHEMBL5556836)
Affinity DataIC50: 0.630nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM681765(US20240199625, Compound 10)
Affinity DataIC50: 0.670nMAssay Description:Compound preparation: Add 45 μL of DMSO to 5 μL of stock solution at a concentration of 10 mM to prepare the solution LY2874455 at 1000 M; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634940(CHEMBL5505810)
Affinity DataIC50: 0.680nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM209275(US9266883, 33)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM209275(US9266883, 33)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559116(CHEMBL4764394)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50606156(CHEMBL5202677)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50606159(CHEMBL5186034)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM597750(US11608332, Example 2 | (S) N-(5-Cyano-4-((2-metho...)
Affinity DataIC50: 0.720nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634948(CHEMBL5532164)
Affinity DataIC50: 0.730nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM597779(US11608332, Example 6 | (S)—N-(5-Cyano-4-((2-...)
Affinity DataIC50: 0.740nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
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US Patent
LigandPNGBDBM597781(US11608332, Example 9 | (R)—N-(5-Cyano-4-((2-...)
Affinity DataIC50: 0.740nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634951(CHEMBL5505915)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634954(CHEMBL5559147)
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50634945(CHEMBL5558932)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559121(CHEMBL4758832)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM604845(N-(5-Cyano-4-(((trans)-2-methoxycyclopentyl)amino)...)
Affinity DataIC50: 0.800nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559128(CHEMBL4742811)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559123(CHEMBL4745780)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559111(CHEMBL4791610)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM50559108(CHEMBL4745615)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Eisai R&D Management

US Patent
LigandPNGBDBM209336(US9266883, 101)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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