Compile Data Set for Download or QSAR
Report error Found 2797 of ic50 data for polymerid = 6551,50007233,50007244
LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human PDE4D using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human PDE4D using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50183792(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183794(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-((3-(6-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183803(N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183805(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353703(CHEMBL1830646)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human recombinant PDE4D using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50: 0.190nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50325788(2-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183808(N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50304417(CHEMBL593656 | cis-(+/-)-4-(3,4-Dimethoxyphenyl)-2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50347344(CHEMBL1801156)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017340(CHEMBL3113734)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM14359(3-[(2S)-2-[3-cyclopropoxy-4-(difluoromethoxy)pheny...)
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM50304410(cis-2-[(E)-4-(1H-Imidazol-1-yl)but-2-enyl]-4-(3,4-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50325790(methyl 2-(4-((8-(3-methoxyphenyl)quinolin-6-yl)met...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353700(CHEMBL1830643)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50174020(L-869298 | (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-diflu...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50347349(CHEMBL1801161)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50183795(2-(8-(3-(((4-fluorobenzyl)(4-(methylsulfonyl)pheny...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50353706(CHEMBL1828652)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50532272(CHEMBL4534321)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50532272(CHEMBL4534321)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50601869(CHEMBL5184286)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50347343(CHEMBL1801155)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50347345(CHEMBL1801157)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50347348(CHEMBL1801160)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232731(2-{3'-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinol...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50232731(2-{3'-[6-(1-methanesulfonyl-1-methyl-ethyl)-quinol...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50347335(CHEMBL1801068)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50347339(CHEMBL1801151)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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