Compile Data Set for Download or QSAR
Report error Found 403 of ic50 data for polymerid = 6547,50002313
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50250586(CHEMBL4093140)
Affinity DataIC50: 0.0100nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Arg-Trp-Asp-Arg-Ph...)
Affinity DataIC50: 0.0740nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Arg-Trp-Asp-Arg-Ph...)
Affinity DataIC50: 0.0741nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50211392(Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys1...)
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50115293(DOTA-ReCCEHdFRWCKPV-OH | CHEMBL436773)
Affinity DataIC50: 0.160nMAssay Description:In vitro binding affinity for the melanoma receptor was determined in the murine melanoma B16/F1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50163144(H-Tyr-Val-Nle-Gly-His-D-Nal(2'')-Arg-D-Phe-Asp-Arg...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]NDP-alphaMSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against hMC1R transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50205745((3S,6S,9R,12S,15S,23S)-15-[(2S)-2-aminohexanamido]...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]NDPalphaMSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.200nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50354719(CHEMBL1834391)
Affinity DataIC50: 0.210nMAssay Description:Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.25nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50354718(CHEMBL1834392)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]-NDP-MSH from mouse melanocortin receptor 1 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting me...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50163145(H-Tyr-Val-Nle-Gly-His-D-Nal(2'')-Arg-D-Trp-Asp-Arg...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Arg-Trp-Asp-Arg-Ph...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50: 0.310nMAssay Description:Displacement of 125I-NDP-MSH from mouse MC1R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50454555(CHEMBL2115441)
Affinity DataIC50: 0.350nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50250591(CHEMBL4072387)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50029748((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)
Affinity DataIC50: 0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50163146(Ac-Tyr-Val-Nle-Gly-His-D-Phe-Arg-Trp-Asp-Arg-Phe-G...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50268806(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50268806(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50: 0.510nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50: 0.510nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 1 receptor at 10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50354717(CHEMBL1834393)
Affinity DataIC50: 0.590nMAssay Description:Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50326435(CHEMBL1240919)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [125I]-(Tyr2)-NDP-MSH from MC1 receptor in mouse B16/F1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50163141(H-Tyr-Val-Nle-Gly-His-D-Phe-Arg-D-Nal(2'')-Asp-Arg...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50468287(CHEMBL4292317)
Affinity DataIC50: 0.740nMAssay Description:Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50354716(CHEMBL1834394)
Affinity DataIC50: 0.760nMAssay Description:Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50115292(DOTA-ReCCEHdFRWCKPVD-OH | CHEMBL438180)
Affinity DataIC50: 0.790nMAssay Description:In vitro binding affinity for the melanoma receptor was determined in the murine melanoma B16/F1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50354715(CHEMBL1834395)
Affinity DataIC50: 0.820nMAssay Description:Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359(MT-II | CHEMBL430239 | Ac-Nle-c[Asp-His-DPhe-Arg-T...)
Affinity DataIC50: 1nMAssay Description:Binding affinity towards human melanocortin receptor (hMC1R) using NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027179(CHEMBL2096759)
Affinity DataIC50: 1nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50121268(21-(2-Acetylamino-hexanoylamino)-7-[3-(diaminometh...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1 receptor expressed in HEK293 cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-[Nle4,d-Phe7]-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50621839(CHEMBL5404193)
Affinity DataIC50: 1nMAssay Description:Displacement of [I125] NDP-alpha-MSH from human MC1R stably overexpressing in HEK293 cells in presence of [I125] labeled NDP-alpha-MSH treated for 40...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50268796(Ac-Nle-c[Asp-cis-4-guanidinyl-Pro-DPhe-Arg-Trp-Lys...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50250590(CHEMBL4081900)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50115291(DOTA-ReCCEHdFRWCKPV-NH2 | CHEMBL269739)
Affinity DataIC50: 1.20nMAssay Description:In vitro binding affinity for the melanoma receptor was determined in the murine melanoma B16/F1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50134948(H-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-Gly-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50268802(Ac-Nle-c[Asp-cis-4-guanidinyl-Pro-DNal(2')-Arg-Trp...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50250585(CHEMBL4104092)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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