Compile Data Set for Download or QSAR
Report error Found 327 of ic50 data for polymerid = 6479,50006069
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50059889(3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of ROS1 by HotSpot assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate in presence of ATP by radiometric HotSpot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.145nMAssay Description:Inhibition of human ROS using KKKSPGEYVNIEFG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.149nMAssay Description:Inhibition of human ROS using KKKSPGEYVNIEFG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
In DepthDetails

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50: 0.205nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144323(US8969336, 567)
Affinity DataIC50: 0.230nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 0.246nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.248nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144318(US8969336, 580 | US8969336, 553)
Affinity DataIC50: 0.290nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM702001(US12129258, Example 24)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50: 0.300nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGUS12129258, Example 1(US20240132517, Comparative Compound 42)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144328(US8969336, 572)
Affinity DataIC50: 0.370nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144321(US8969336, 565)
Affinity DataIC50: 0.400nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144319(US8969336, 581 | US8969336, 554)
Affinity DataIC50: 0.410nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50512149(CHEMBL4470529)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50: 0.436nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647635(US20240025908, Example 3 | T-05)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647636(US20240025908, Example 4 | T-07)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647638(US20240025908, Example 6 | T-12)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647639(US20240025908, Example 7 | T-17)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647640(US20240025908, Example 8 | T-36)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647641(US20240025908, Example 9 | T-37)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647642(US20240025908, Example 10 | T-42)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647652(US20240025908, Example 20)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647653(US20240025908, Example 21)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647654(US20240025908, Example 22)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647655(US20240025908, Example 23)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647657(US20240025908, Example 25)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM647658(US20240025908, Example 26)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of protein kinase activity by compounds was carried out on the Radio-tagged HotSpot kinase experimental platform of Reaction Biology Corpo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144326(US8969336, 570)
Affinity DataIC50: 0.510nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144316(US8969336, 578 | US8969336, 549)
Affinity DataIC50: 0.510nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM702002(US12129258, Example 9)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144317(US8969336, 579 | US8969336, 550)
Affinity DataIC50: 0.580nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144325(US8969336, 569)
Affinity DataIC50: 0.650nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50: 0.688nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM267453(US9718822, 36 | US9750744, Example 36 | US9902741,...)
Affinity DataIC50: 0.700nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM267453(US9718822, 36 | US9750744, Example 36 | US9902741,...)
Affinity DataIC50: 0.700nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50525830(CHEMBL4562805)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS (1883 to 2347 residues) cytoplasmic domain expressed in baculovirus expression system using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50512152(CHEMBL4573193)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144329(US8969336, 573)
Affinity DataIC50: 0.780nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM701999(US12129258, Example 6)
Affinity DataIC50: 0.780nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50512153(CHEMBL4447747)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM144322(US8969336, 566)
Affinity DataIC50: 0.860nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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