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TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50134803(5,8-Dimethyl-11-(6-oxiranyl-6-oxo-hexyl)-decahydro...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Histone deacetylase 4 in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162854(US9056843, 145)
Affinity DataIC50: 0.75nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.850nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50: 0.970nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162848(US9056843, 139)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162859(US9056843, 150)
Affinity DataIC50: 1.10nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162852(US9056843, 143)
Affinity DataIC50: 1.20nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50268097(6-{[2-(9H-Fluoren-9-yliden)acetyl]amino}-N-hydroxy...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162850(US9056843, 141)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162855(US9056843, 146)
Affinity DataIC50: 1.60nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222728(cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) | CHEMBL3942...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222736(cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) | CHEMBL...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162860(US9056843, 151)
Affinity DataIC50: 1.80nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222732(cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) | (5S,11S,13a...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM152481(Z-L-Am7(betaMe)-QA (3))
Affinity DataIC50: 2nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19130(CHEMBL99 | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50531365(CHEMBL4438404)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50552912(CHEMBL4760047)
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222730(cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) | CHEMBL...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222735(cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) | CHEMBL39...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HDAC4 catalytic domain expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222729(cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) | CHEMBL39138...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50134799(6-((5S,8S,11S,13aR)-5,8-Dimethyl-4,7,10,13-tetraox...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Histone deacetylase 4 in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50002747(CHEMBL217546)
Affinity DataIC50: 2.83nMAssay Description:Inhibition of maize HD1-A (mean)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50051031(CHEMBL2158745)
Affinity DataIC50: 3nMAssay Description:Inhibition of human HDAC4 expressed in HEK293T cells assessed as aminomethyl coumarin release using Ac-KGLGK(Ac)-MCA) substrate after 30 mins by FLIP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM228164(US10047073, 6 | US10047073, 7)
Affinity DataIC50: 3nMAssay Description:The Class I HDAC activity of Class IIa Histone Deacetylase (HDAC) inhibitors was quantified by measuring the cellular histone deacetylase enzymatic a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged HDAC4 expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50552909(CHEMBL4754665)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant HDAC4 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222738(cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) | CHEMBL39138...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM152482((Z-L-Am7(S-)-QA)2 (4))
Affinity DataIC50: 3.40nMAssay Description:For the enzyme assay, 10 µL of the enzyme fraction was added to 1 µL of fluorescent substrate (2 mM Ac-KGLGK(Ac)-MCA) and 9 µL of histone deacetylase...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50531366(CHEMBL4543038)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162862(US9056843, 153)
Affinity DataIC50: 3.60nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50268042((2E,4E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-methyl-5...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222733(cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) | CHEMBL39396...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50048860(CHEMBL3310508)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human HDAC4 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreito...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 4(Human)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222737(cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) | CHEMBL23858...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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