Compile Data Set for Download or QSAR
Report error Found 709 of ic50 data for polymerid = 5999,7926,50007119
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437709(US10617706, Example 143)
Affinity DataIC50: 3.85nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437686(US10617706, Example 120)
Affinity DataIC50: 5.01nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437707(US10617706, Example 141)
Affinity DataIC50: 6.09nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521692(CHEMBL4441013)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437708(US10617706, Example 142)
Affinity DataIC50: 6.49nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521699(CHEMBL4572376)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437703(US10617706, Example 137)
Affinity DataIC50: 7.25nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521689(CHEMBL4436202)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437685(US10617706, Example 119)
Affinity DataIC50: 8.28nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437705(US10617706, Example 139)
Affinity DataIC50: 13.6nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521691(CHEMBL4587441)
Affinity DataIC50: 14nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437704(US10617706, Example 138)
Affinity DataIC50: 19.8nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521690(CHEMBL4520052)
Affinity DataIC50: 20nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 25nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437694(US10617706, Example 128)
Affinity DataIC50: 32.8nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 33nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521687(CHEMBL4560735)
Affinity DataIC50: 33nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521697(CHEMBL4468174)
Affinity DataIC50: 33nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437692(US10617706, Example 126)
Affinity DataIC50: 33.1nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437697(US10617706, Example 131)
Affinity DataIC50: 35nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521698(CHEMBL4555612)
Affinity DataIC50: 35nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437696(US10617706, Example 130)
Affinity DataIC50: 38nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521678(CHEMBL4521151)
Affinity DataIC50: 38nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437689(US10617706, Example 123)
Affinity DataIC50: 39nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50518351(CHEMBL4470500)
Affinity DataIC50: 40nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438848(CHEMBL2420480)
Affinity DataIC50: 41nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438864(CHEMBL2420507)
Affinity DataIC50: 42nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437687(US10617706, Example 121)
Affinity DataIC50: 47nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437699(US10617706, Example 133)
Affinity DataIC50: 59nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 62nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437695(US10617706, Example 129)
Affinity DataIC50: 64.7nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521701(CHEMBL4457155)
Affinity DataIC50: 65nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521688(CHEMBL4546104)
Affinity DataIC50: 70nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437693(US10617706, Example 127)
Affinity DataIC50: 70.4nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437698(US10617706, Example 132)
Affinity DataIC50: 119nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437702(US10617706, Example 136)
Affinity DataIC50: 119nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521702(CHEMBL4518508)
Affinity DataIC50: 130nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437683(US10617706, Example 117)
Affinity DataIC50: 131nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 140nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521683(CHEMBL4576353)
Affinity DataIC50: 150nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437682(US10617706, Example 116)
Affinity DataIC50: 153nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM34905(1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...)
Affinity DataIC50: 161nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 180nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437701(US10617706, Example 135)
Affinity DataIC50: 185nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437675(US10617706, Example 110 | US10617706, Example 109)
Affinity DataIC50: 186nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521686(CHEMBL4557001)
Affinity DataIC50: 190nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM437677(US10617706, Example 111)
Affinity DataIC50: 196nMAssay Description:The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosyl-DNA phosphodiesterase 2(Human)
Regents of The University of Minnesota

US Patent
LigandPNGBDBM50521681(CHEMBL4464179)
Affinity DataIC50: 200nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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