Compile Data Set for Download or QSAR
Report error Found 1168 of ic50 data for polymerid = 5682,49000371,49000373,50000830
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419522(CHEMBL1924027)
Affinity DataIC50: 0.0316nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296345(Tiotropium Bromide | (1R,2R,4S,5R,7S)-7-(2-hydroxy...)
Affinity DataIC50: 0.0501nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419512(CHEMBL1924040)
Affinity DataIC50: 0.0501nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419531(CHEMBL1921908)
Affinity DataIC50: 0.0501nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419493(CHEMBL1921925)
Affinity DataIC50: 0.0631nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419504(CHEMBL1921907)
Affinity DataIC50: 0.0631nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419538(CHEMBL1921935)
Affinity DataIC50: 0.0631nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419484(CHEMBL1921937)
Affinity DataIC50: 0.0794nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419541(CHEMBL1921917)
Affinity DataIC50: 0.0794nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419478(CHEMBL1921945)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419533(CHEMBL1924036)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419535(CHEMBL1922053)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296331((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phe...)
Affinity DataIC50: 0.126nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419477(CHEMBL1921946)
Affinity DataIC50: 0.126nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419481(CHEMBL1921941)
Affinity DataIC50: 0.126nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419506(CHEMBL1924049)
Affinity DataIC50: 0.126nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419527(CHEMBL1921919)
Affinity DataIC50: 0.126nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624956(US20230322745, Compound 28)
Affinity DataIC50: 0.136nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419472(CHEMBL1922054)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419474(CHEMBL1922051)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419498(CHEMBL1921918)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419501(CHEMBL1921911)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419505(CHEMBL1921904)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419528(CHEMBL1924025)
Affinity DataIC50: 0.158nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296331((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phe...)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624955(US20230322745, Compound 25)
Affinity DataIC50: 0.179nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296336((3R)-3-{[(2S)-2-Cyclopentyl-2-hydroxy-2-(2-thienyl...)
Affinity DataIC50: 0.180nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624948(US20230322745, Compound 16 | US20230322745, Compou...)
Affinity DataIC50: 0.198nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM200747(US9233108, 9 | US9757383, Example 9)
Affinity DataIC50: 0.200nMAssay Description:The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM221898(US9315463, 1)
Affinity DataIC50: 0.200nMAssay Description:The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50344294((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-3-ylmeth...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419471(CHEMBL1922055)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419473(CHEMBL1922052)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419475(CHEMBL1922050)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419479(CHEMBL1921944)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419480(CHEMBL1921943)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419482(CHEMBL1921940)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419499(CHEMBL1921914)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419503(CHEMBL1921910)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419537(CHEMBL1921942)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419491(CHEMBL1921927)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296329((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(2-phe...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM200747(US9233108, 9 | US9757383, Example 9)
Affinity DataIC50: 0.200nMAssay Description:The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624969(US20230322745, Compound 41)
Affinity DataIC50: 0.201nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624962(US20230322745, Compound 35)
Affinity DataIC50: 0.213nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM624953(US20230322745, Compound 24)
Affinity DataIC50: 0.220nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296317((3R)-1-Azabicyclo[2.2.2]oct-3-ylhydroxy(di-2-thien...)
Affinity DataIC50: 0.230nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM123054(US8742134, (1))
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/mole IC50: 0.230nMT: 2°CAssay Description:Radioligand binding studies were carried out with M3 receptor cell homogenates as described (Peralta et al., The EMBO Journal 6, 3923-3929, (1987)). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296338((3R)-3-{[(9-Methyl-9H-xanthen-9-yl)carbonyl]oxy}-1...)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50296341((3R)-3-{[Hydroxy(di-3-thienyl)acetyl]oxy}-1-(3-phe...)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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