Compile Data Set for Download or QSAR
Report error Found 2044 of ic50 data for polymerid = 5625,49001064,50007752
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235368(US9393245, 98 | US10085990, Example 98)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235381(US9393245, 113 | BDBM287835)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235363(US9393245, 93 | US10085990, Example 93)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235364(US9393245, 94 | US10085990, Example 94)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235366(US9393245, 96 | US10085990, Example 96)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM77003(3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy...)
Affinity DataIC50: 0.520nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM65497(CC-220 (Compound 6) | US9694015, 6.4S)
Affinity DataIC50: 0.590nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235367(US9393245, 97 | US10085990, Example 97)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM77008(3-{4-[4-(2-morpholin-4-yl-ethyl)-benzyloxy]-1-oxo-...)
Affinity DataIC50: 0.790nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235370(US9393245, 100 | US10085990, Example 100)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM77005(3-(4-(4-(2-morpholin-4-yl-ethoxy)-benzyloxy)-1-oxo...)
Affinity DataIC50: 0.960nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235350(US9393245, 78 | US10085990, Example 78)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235355(US9393245, 83 | US10085990, Example 83)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235359(US9393245, 88 | US10085990, Example 88)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235362(US9393245, 91 | US10085990, Example 91)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235365(US9393245, 95 | US10085990, Example 95)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM135819(US8853226, 103 | US9393245, 103 | US10085990, Exam...)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235375(US9393245, 107 | US10085990, Example 107)
Affinity DataIC50: 1nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM77001(3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoisoin...)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM135817(US8853226, 84 | US9393245, 84 | US10085990, Exampl...)
Affinity DataIC50: 2nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235358(US9393245, 87 | US10085990, Example 87)
Affinity DataIC50: 2nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235361(US9393245, 90 | US10085990, Example 90)
Affinity DataIC50: 2nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235383(US9393245, 116 | US10085990, Example 116)
Affinity DataIC50: 2nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235390(US9393245, 126 | US10085990, Example 126)
Affinity DataIC50: 2nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US8853226, 92 | US9393245, 92 | US10085990, Exampl...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235344(US9393245, 72 | US10085990, Example 72)
Affinity DataIC50: 4nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235374(US9393245, 106 | US10085990, Example 106)
Affinity DataIC50: 4nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM511474(US11059789, Example 23 | US11691950, Example 23)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM511474(US11059789, Example 23 | US11691950, Example 23)
Affinity DataIC50: 4.5nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235360(US9393245, 89 | US10085990, Example 89)
Affinity DataIC50: 5nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM135816(US8853226, 54 | US9393245, 54 | US10085990, Exampl...)
Affinity DataIC50: 6nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235347(US9393245, 75 | US10085990, Example 75)
Affinity DataIC50: 6nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM135824(US8853226, 127 | US9393245, 127 | US10085990, Exam...)
Affinity DataIC50: 6nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235377(US9393245, 109 | US10085990, Example 109)
Affinity DataIC50: 8nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235345(US9393245, 73 | US10085990, Example 73)
Affinity DataIC50: 9nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM77015((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...)
Affinity DataIC50: 9.5nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM277677(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Affinity DataIC50: 10.8nMAssay Description:PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552364(CHEMBL4781606)
Affinity DataIC50: 14nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552380(CHEMBL4797699)
Affinity DataIC50: 15nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552381(CHEMBL4787433)
Affinity DataIC50: 15nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM309962(US9656996, Compound 18)
Affinity DataIC50: 15.2nMAssay Description:1. Buffer preparation: 50 mM HEPES, pH 7.5, 3 mM MgCl2, 1 mM EGTA, 100 mM NaCl, 0.03% CHAPS.2. The compound was formulated in 100% DMSO in a concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM511476(US11059789, Example 28 | US11691950, Example 28)
Affinity DataIC50: 15.5nMAssay Description:Inhibition of various kinases was assayed.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM511476(US11059789, Example 28 | US11691950, Example 28)
Affinity DataIC50: 15.5nMAssay Description:The TNFα assay quantifies secreted TNFα from RAW264.7 immortalized murine macrophages as an indicator of inflammation. The cells were concu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552368(CHEMBL4787001)
Affinity DataIC50: 17nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM235369(US9393245, 99 | US10085990, Example 99)
Affinity DataIC50: 20nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM102834(US8541572, 911)
Affinity DataKi:  0.160nM IC50: 20nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM309961(US9656996, Compound 16)
Affinity DataIC50: 20.1nMAssay Description:1. Buffer preparation: 50 mM HEPES, pH 7.5, 3 mM MgCl2, 1 mM EGTA, 100 mM NaCl, 0.03% CHAPS.2. The compound was formulated in 100% DMSO in a concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552388(CHEMBL4742065)
Affinity DataIC50: 24nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTumor necrosis factor(Human)
Vtv Therapeutics

US Patent
LigandPNGBDBM50552388(CHEMBL4742065)
Affinity DataIC50: 24nMAssay Description:Displacement of fluorescent labeled probe from human recombinant His-tagged TNFalpha (77 to 233 residues) expressed in Escherichia coli preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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