Compile Data Set for Download or QSAR
Report error Found 696 of ic50 data for polymerid = 5566,49000791,49000792,49000793,49000795,50000014,50006859
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataIC50: 0.210nMAssay Description:Compound was tested for binding affinity against human Tachykinin receptor 3 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeuromedin-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50: 0.720nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194553(N'-[3-(4-benzenesulfonyl-piperazin-1-ylmethyl)-2-p...)
Affinity DataIC50: 0.720nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291261(SR-14280 | SR-142801 | (S)-(+)-N-((3-[1-Benzoyl-3-...)
Affinity DataIC50: 0.800nMAssay Description:Tachykinin receptor 3 binding affinity was determined by incubation with CHO cells expressing human NK3 receptorsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194591(3-methoxy-N',N',2-triphenylquinoline-4-carbohydraz...)
Affinity DataIC50: 0.850nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052524((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50070355(3-(3,4-dichlorophenyl)-3-{3-[1-methylsulfonylspiro...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194573(N'-{8-fluoro-3-[4-(1-methyl-cyclohexyl)-piperazin-...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50070351(1-(1-{3-[1-Benzoyl-3-(3,4-dichloro-phenyl)-piperid...)
Affinity DataIC50: 1.5nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432275(CHEMBL2347488)
Affinity DataIC50: 1.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432242(CHEMBL2347361)
Affinity DataIC50: 1.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194564(N'-[3-(4-benzyl-piperazin-1-ylmethyl)-2-phenyl-qui...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50180193(AZD2624 | AZD-2624)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432267(CHEMBL2347496)
Affinity DataIC50: 1.70nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432241(CHEMBL2347362)
Affinity DataIC50: 1.80nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194557(N-phenyl-N'-{2-phenyl-3-[4-(tetrahydro-thiopyran-4...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081196(US9475814, 13 | CHEMBL3422015 | US10065961, Compou...)
Affinity DataIC50: 2nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081198(US9475814, 24 | CHEMBL3422018 | US10065961, Compou...)
Affinity DataIC50: 2nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194567(N'-[3-(4-cyclohexyl-piperazin-1-ylmethyl)-2-phenyl...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081196(US9475814, 13 | CHEMBL3422015 | US10065961, Compou...)
Affinity DataIC50: 2nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081198(US9475814, 24 | CHEMBL3422018 | US10065961, Compou...)
Affinity DataIC50: 2nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051293(SB-2234 | 3-Hydroxy-2-phenyl-quinoline-4-carboxyli...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432245(CHEMBL2347511)
Affinity DataIC50: 2.5nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50070360(3-(3,4-dichlorophenyl)-3-[3-spiro[2,3-dihydro-1H-i...)
Affinity DataIC50: 2.60nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50090485(spiro[(2-hydroxy)indane-1,40-piperidine] analogue ...)
Affinity DataIC50: 2.70nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 3 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251907(US9475814, 5 | US10065961, Compound 5 | US10683295...)
Affinity DataIC50: 3nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251909(US9475814, 7 | US10065961, Compound 7 | US10683295...)
Affinity DataIC50: 3nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251923(US9475814, 25 | BDBM272562 | US10683295, Compound ...)
Affinity DataIC50: 3nMAssay Description:Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194556(N'-[3-(4-tert-butyl-piperazin-1-ylmethyl)-8-fluoro...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of inositol phosphate generationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50079412((NKB)Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |...)
Affinity DataIC50: 3nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50299467((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)
Affinity DataIC50: 3nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251907(US9475814, 5 | US10065961, Compound 5 | US10683295...)
Affinity DataIC50: 3nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251909(US9475814, 7 | US10065961, Compound 7 | US10683295...)
Affinity DataIC50: 3nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM251923(US9475814, 25 | BDBM272562 | US10683295, Compound ...)
Affinity DataIC50: 3nMAssay Description:The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194570(N-phenyl-N'-{2-phenyl-3-[4-(tetrahydro-pyran-4-yl)...)
Affinity DataIC50: 3.30nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194561(N'-{8-fluoro-2-phenyl-3-[4-(tetrahydro-pyran-4-yl)...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194565(N'-{8-fluoro-3-[4-(4-methyl-tetrahydro-pyran-4-yl)...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50432269(CHEMBL2347494)
Affinity DataIC50: 3.60nMAssay Description:Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50050641([(R)-2-(2,3-Difluoro-phenyl)-1-methyl-1-(7-ureido-...)
Affinity DataIC50: 3.70nMAssay Description:Compound was tested for binding affinity towards Tachykinin receptor 3 binding sites in guinea pig cortical membranes using [125I][MePhe7]-NKB as rad...More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50050641([(R)-2-(2,3-Difluoro-phenyl)-1-methyl-1-(7-ureido-...)
Affinity DataIC50: 3.70nMAssay Description:Compound was tested for binding affinity towards Tachykinin receptor 3 binding sites in guinea pig cortical membranes using [125I][MePhe7]-NKB as rad...More data for this Ligand-Target Pair
In DepthDetails Article

TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50180171(CHEMBL3813763)
Affinity DataIC50: 3.90nMAssay Description:Displacement of [125I]His3-MePhe7)-NKB from human NK3R expressed in CHO cell membranes by topcounting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50050641([(R)-2-(2,3-Difluoro-phenyl)-1-methyl-1-(7-ureido-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I]-[MePhe7]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081396(CHEMBL3422014)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human NK3R expressed in CHO cells assessed as inhibition of NKB-induced Ca2+ signaling by aequorin Ca2+ biolumines...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081196(US9475814, 13 | CHEMBL3422015 | US10065961, Compou...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human NK3R expressed in CHO cells assessed as inhibition of NKB-induced Ca2+ signaling by aequorin Ca2+ biolumines...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081198(US9475814, 24 | CHEMBL3422018 | US10065961, Compou...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human NK3R expressed in CHO cells assessed as inhibition of NKB-induced Ca2+ signaling by aequorin Ca2+ biolumines...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50194556(N'-[3-(4-tert-butyl-piperazin-1-ylmethyl)-8-fluoro...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]neurokinin B from human cloned NK3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50081198(US9475814, 24 | CHEMBL3422018 | US10065961, Compou...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human recombinant NK3R expressed in CHO cells by aequorin functional assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuromedin-K receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50050641([(R)-2-(2,3-Difluoro-phenyl)-1-methyl-1-(7-ureido-...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against Tachykinin receptor 3 in guinea pig cortical membranes labeled with [125 I]-[MePhe7]More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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