Compile Data Set for Download or QSAR
Report error Found 399 of ic50 data for polymerid = 5459,49000785,49000786,49000788,50000086,50000863,50001817
TargetSubstance-K receptor(Golden hamster)
TBA

Curated by ChEMBL
LigandPNGBDBM50366377(MEN-10627 | CHEMBL334721)
Affinity DataIC50: 0.0790nMAssay Description:Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071484(N-[(R)-4-(4-Acetylamino-4-phenyl-piperidin-1-yl)-2...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97485(US8470816, 458)
Affinity DataIC50: 0.220nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97486(US8470816, 464)
Affinity DataIC50: 0.220nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97489(US8470816, 632)
Affinity DataIC50: 0.220nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97481(US8470816, 265)
Affinity DataIC50: 0.230nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97490(US8470816, 633)
Affinity DataIC50: 0.240nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97483(US8470816, 292)
Affinity DataIC50: 0.25nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97479(US8470816, 251a)
Affinity DataIC50: 0.310nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97487(US8470816, 623)
Affinity DataIC50: 0.310nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97491(US8470816, 635)
Affinity DataIC50: 0.360nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170968((S)-5-(3,4-Dichloro-phenyl)-1-(4,4-difluoro-cycloh...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97482(US8470816, 268)
Affinity DataIC50: 0.420nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071484(N-[(R)-4-(4-Acetylamino-4-phenyl-piperidin-1-yl)-2...)
Affinity DataIC50: 0.440nMAssay Description:Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKAMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97472(US8470816, 18)
Affinity DataIC50: 0.450nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97488(US8470816, 629)
Affinity DataIC50: 0.550nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97480(US8470816, 252)
Affinity DataIC50: 0.560nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97478(US8470816, 91)
Affinity DataIC50: 0.790nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50409627(CHEMBL185572)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071484(N-[(R)-4-(4-Acetylamino-4-phenyl-piperidin-1-yl)-2...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97484(US8470816, 318)
Affinity DataIC50: 0.820nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Golden hamster)
TBA

Curated by ChEMBL
LigandPNGBDBM50001435(3-Amino-N-[1-(1-{1-[2-(1-{[(1-carbamoyl-2-phenyl-e...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Golden hamster)
TBA

Curated by ChEMBL
LigandPNGBDBM50001447(His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(Neurok...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410049(CHEMBL434142)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97475(US8470816, 30)
Affinity DataIC50: 1.10nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410051(CHEMBL185182)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410048(CHEMBL434548)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97476(US8470816, 31)
Affinity DataIC50: 1.70nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001447(His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(Neurok...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against human Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97474(US8470816, 24)
Affinity DataIC50: 2nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM106976(US8592454, 66)
Affinity DataIC50: 2nMAssay Description:Radioligand receptor binding inhibitory assay using human NK receptor.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50290298((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97477(US8470816, 82)
Affinity DataIC50: 2.20nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50290306((1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimet...)
Affinity DataIC50: 2.20nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070352(1-benzyl-5-(3,4-dichlorophenyl)-5-{3-[1-methylsulf...)
Affinity DataIC50: 2.20nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM97473(US8470816, 21)
Affinity DataIC50: 2.30nMpH: 7.5Assay Description:CHO cells expressing hNK2 receptor were cultured in a HAM-F12 medium containing 400 ug/mL geneticin, 100 U/mL penicillin, 100 ug/mL streptomycin and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175505(1-{2-[1-Benzoyl-3-((S)-3,4-dichloro-phenyl)-pyrrol...)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory concentration against tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM106981(US8592454, 308)
Affinity DataIC50: 2.40nMAssay Description:Radioligand receptor binding inhibitory assay using human NK receptor.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50097911(5-Fluoro-3-[3-(4-methoxy-4-(methylsulfinyl)benzene...)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070358(8-{3-[1-Benzyl-3-(3,4-dichloro-phenyl)-6-oxo-piper...)
Affinity DataIC50: 2.5nMAssay Description:Compound was evaluated for affinity towards human Neurokinin NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50435131(CHEMBL2390989)
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to human NK2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410054(CHEMBL185133)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217519(CHEMBL354709)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50403793(CHEMBL2115415)
Affinity DataIC50: 3.10nMAssay Description:The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50290303((1-{2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy...)
Affinity DataIC50: 3.10nMAssay Description:Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50410052(CHEMBL367815)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Neurokinin 2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Guinea pig)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50217520(CHEMBL354645)
Affinity DataIC50: 3.20nMAssay Description:Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155253(CHEMBL3775108)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSubstance-K receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50435131(CHEMBL2390989)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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