Compile Data Set for Download or QSAR
Report error Found 12480 of ic50 data for polymerid = 5405,50000828,50007424
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50515378(CHEMBL4443947)
Affinity DataIC50: 0.0220nMAssay Description:Binding affinity to human IRK4 using myelin basic protein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511360(CHEMBL4556091)
Affinity DataIC50: 0.0260nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50599226(CHEMBL5201062 | US11866405, Example 100)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50599226(CHEMBL5201062 | US11866405, Example 100)
Affinity DataIC50: 0.0300nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511348(CHEMBL4566431 | US11034698, Example 105)
Affinity DataIC50: 0.0780nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511359(CHEMBL4545898 | US10988478, Example 258)
Affinity DataIC50: 0.0810nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50515375(CHEMBL4448950)
Affinity DataIC50: 0.0990nMAssay Description:Binding affinity to human IRK4 using myelin basic protein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM319575(5-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403204(US10329302, Example 360 | US10793579, Example 360 ...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403214(US10329302, Example 370 | US10793579, Example 370 ...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665883(US20240116922, Example 185)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665897(US20240116922, Comparator 3A)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50599222(CHEMBL5190644 | US11866405, Example 12)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus infected insect cells using KKARFSRFAGSSPSQSSMVAR as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665902(US20240116922, Comparator 5A)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665806(US20240116922, Example 108 | (R)-N-(1-cyclopropyl-...)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665912(US20240116922, Comparator 3B)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403204(US10329302, Example 360 | US10793579, Example 360 ...)
Affinity DataIC50: 0.100nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403214(US10329302, Example 370 | US10793579, Example 370 ...)
Affinity DataIC50: 0.100nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511361(CHEMBL4445098)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665703(US20240116922, Example 5)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665704(US20240116922, Example 6)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length IRAK4 (unknown origin) in presence of ATP by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665859(US20240116922, Example 161 | 7-((S)-sec-butoxy)-N-...)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403204(US10329302, Example 360 | US10793579, Example 360 ...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Protocol B: To begin the assay, 45 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 228 μ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM665863(US20240116922, Example 165 | N-(1-((1R,2S)-2-fluor...)
Affinity DataIC50: 0.100nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403214(US10329302, Example 370 | US10793579, Example 370 ...)
Affinity DataIC50: 0.100nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50599222(CHEMBL5190644 | US11866405, Example 12)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against IRAK4 were determined in an enzymatic assay using mass spectrometry readout. Ten point half-log compound...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511366(CHEMBL4568894)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511358(CHEMBL4472406 | US10988478, Example 175)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50511349(CHEMBL4475494 | US10988478, Example 139)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM278744(2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[3- (difluor...)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM278845(2[(3R)-3- aminopiperidin-1-yl] N-[3-(difluoromethy...)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM278846(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[3-(diflu...)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM278854(2-[(3S)- or (3R)- azepan-3-ylamino]-N- [3-(difluor...)
Affinity DataIC50: 0.200nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50068540(CHEMBL3403457 | US9598440, 68)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM302970(US9598440, 111)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM302972(US9598440, 113)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM302983(US9598440, 124)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM302992(US9598440, 133)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM302996(US9598440, 137)
Affinity DataIC50: 0.200nMAssay Description:Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.200nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM403169(US10329302, Example 323 | US10793579, Example 323 ...)
Affinity DataIC50: 0.200nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.200nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
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