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TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK4 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human N-terminal GST-fused PAK4 (1 to 591 residues) expressed in baculovirus expression system using S2 as substrate measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50600087(CHEMBL5180027)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50043014(CHEMBL3355023)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50591962(CHEMBL5175418)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PAK4 (unknown origin) using S2 as substrate incubated for 60 mins in the presence of ATP by time-resolved HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50591962(CHEMBL5175418)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PAK4 (unknown origin) using S2 substrate incubated for 60 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50591962(CHEMBL5175418)
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human N-terminal GST-fused PAK4 (1 to 591 residues) expressed in baculovirus expression system using S2 as substrate measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50251098(CHEMBL4097816)
Affinity DataIC50: 9nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634059(CHEMBL5429021)
Affinity DataIC50: 9nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 9nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442757(CHEMBL2443026)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442758(CHEMBL2443139)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442759(CHEMBL2443138)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50442760(CHEMBL2443044)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634054(CHEMBL5411182)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50251098(CHEMBL4097816)
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged human PAK4 (295 to 591 residues) expressed in Baculovirus expression system by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634058(CHEMBL5400697)
Affinity DataIC50: 11nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634056(CHEMBL5395115)
Affinity DataIC50: 13nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50237832(CHEMBL1198335)
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK4 (unknown origin) assessed as reduction in histone phosphorylation incubated for 1 hr at 4 degC by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 15nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50: 16nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252687(CHEMBL4078441)
Affinity DataIC50: 16nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634055(CHEMBL5414332)
Affinity DataIC50: 16nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 18nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human PAK4 kinase domain (300 to 591) using peptide 7 as substrate by pyruvate kinase/lactate dehydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged PAK4 expressed in bacterial expression system by pyruvate kinase/LDH enzyme coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged PAK4 kinase domain (300 to 591 residues) incubated in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50600088(CHEMBL5183512)
Affinity DataIC50: 20nMAssay Description:Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252732(CHEMBL4104099)
Affinity DataIC50: 22nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252732(CHEMBL4104099)
Affinity DataIC50: 22nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human PAK4 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 24nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM101536(US8530652, 63 | CHEMBL3128043 | US8530494, 203)
Affinity DataIC50: 24nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50634057(CHEMBL5401120)
Affinity DataIC50: 24nMAssay Description:Inhibition of PAK4 (unknown origin) using lipid substrate incubated for 40 mins in presence of ATP by ADP-Glo plus luminescence kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449495(CHEMBL4160587)
Affinity DataIC50: 25nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50615896(CHEMBL5282566)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252688(CHEMBL4088781)
Affinity DataIC50: 27nMAssay Description:Inhibition of PAK4 (unknown origin) using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 27.9nMAssay Description:Inhibition of human PAK4 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50252688(CHEMBL4088781)
Affinity DataIC50: 28nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Inner Mongolia Medical University

Curated by ChEMBL
LigandPNGBDBM50449511(CHEMBL4164650)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length human PAK4 using substrate S2 after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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