Compile Data Set for Download or QSAR
Report error Found 72 of ic50 data for polymerid = 5124,50002567
LigandPNGBDBM50243461(CHEMBL4075503)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243462(CHEMBL4083899)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243463(CHEMBL4100363)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243486(CHEMBL4081385)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243487(CHEMBL4091668)
Affinity DataIC50: 12nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243441(CHEMBL4076500)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243443(CHEMBL4070790)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243485(CHEMBL4074469)
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243415(CHEMBL4063104)
Affinity DataIC50: 16nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243434(CHEMBL4079085)
Affinity DataIC50: 18nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243442(CHEMBL4099409)
Affinity DataIC50: 20nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243433(CHEMBL4101204)
Affinity DataIC50: 26nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50369444(CHEMBL608337)
Affinity DataIC50: 125nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158378(5-(5-sulfamoyl-naphthalen-2-ylazo)-naphthalene-1-s...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243477(CHEMBL4092503)
Affinity DataIC50: 608nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Affinity DataIC50: 700nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005520(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Affinity DataIC50: 700nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243414(CHEMBL4084757)
Affinity DataIC50: 723nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243396(CHEMBL1231520)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22584({4-[5-bromo-3-(sulfooxy)-1H-indol-2-yl]-13-chloro-...)
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Affinity DataIC50: 1.90E+3nMAssay Description:Triglutamyl homologue inhibition activity against AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Mouse)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Affinity DataIC50: 1.90E+3nMAssay Description:Triglutamyl homologue inhibition activity against AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22580(5-chloro-2-{5-hydroxy-3-methyl-4-[(E)-2-[4-(4-meth...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22580(5-chloro-2-{5-hydroxy-3-methyl-4-[(E)-2-[4-(4-meth...)
Affinity DataIC50: 3.30E+3nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158388(4-(1-aminonaphthalene-6-sulfonamido)benzoic acid |...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50080319(10-Formyl-8-deazafolic acid | CHEMBL114215)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022388(2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyri...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibitory activity against AICAR formyltransferase of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158380(3-(4-amino-2-methyl-phenylazo)-naphthalene-1,5-dis...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158381((Z)-1,2-bis(4-sulfonaphthalen-2-yl)diazene oxide |...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158387(NSC-292213 | 4-[(3-carboxy-4-hydroxy-1-naphthyl)(o...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158382(N'-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22582(CHEMBL222602 | 4-{3-methyl-4-[(E)-2-[3-methyl-4-(p...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22582(CHEMBL222602 | 4-{3-methyl-4-[(E)-2-[3-methyl-4-(p...)
Affinity DataIC50: 1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158386(5-hydroxy-8-[4-(4-sulfo-phenylazo)-phenylazo]-naph...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22578(2-[(E)-2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfoph...)
Affinity DataKi:  7.10E+3nM ΔG°:  -29.1kJ/mole IC50: 1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50158383(2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50158385(2-(4-aminobenzamido)-5-(6-methylbenzo[d]thiazol-2-...)
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50003058(CHEMBL331208 | 2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5...)
Affinity DataIC50: 1.70E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243413(CHEMBL4077027)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AICAR formyltransferase of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022387(2-{4-[(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AICAR formyltransferase of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022386(2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyri...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AICAR formyltransferase of Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compound was tested for inhibition of AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50022739((6RS) 2-{4-[2-(2-Amino-5-ethyl-4-oxo-3,4,5,6,7,8-h...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compound was tested for inhibition of AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22583(yellow 2G | C.I. Food Yellow 5 | CHEMBL222654 | 2,...)
Affinity DataIC50: 2.01E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22583(yellow 2G | C.I. Food Yellow 5 | CHEMBL222654 | 2,...)
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22579(Aminoimidazole-4-carboxamide ribonucleotide | CHEM...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50041176(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory concentration against Lactobacillus casei AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50041179(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory concentration against Lactobacillus casei AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50243508(CHEMBL4101760)
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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