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TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538571(CHEMBL4635160)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GST-tagged UCHL5 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50072959(CHEMBL3410535)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of GST-tagged UCHL5 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM65518(LDN-57444 | 668467-91-2 | 5-Chloro-1-[(2,5-dichlor...)
Affinity DataIC50: 1.62E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242207(Mangiferin | CHEMBL455364)
Affinity DataIC50: 3.00E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552483(CHEMBL4763594)
Affinity DataIC50: 3.29E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50442907(CHEMBL3039433 | Acetyl Isogambogic Acid)
Affinity DataIC50: 3.65E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50072960(CHEMBL3410537)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of GST-tagged UCHL5 (unknown origin) using Ub-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM205457(Celastrol | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-...)
Affinity DataIC50: 5.66E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM200235(Rifampicin | cid_5381226)
Affinity DataIC50: 6.28E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552481(CHEMBL4761097)
Affinity DataIC50: 7.26E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552486(CHEMBL4785714)
Affinity DataIC50: 7.57E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552484(CHEMBL4787127)
Affinity DataIC50: 8.05E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552478(CHEMBL4795817)
Affinity DataIC50: 8.09E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552476(CHEMBL4747595)
Affinity DataIC50: 8.45E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552485(CHEMBL4741346)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552479(CHEMBL4745257)
Affinity DataIC50: 9.62E+4nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM65524((-)-Aricine | Heterophylline (VAN) | Quinovatine)
Affinity DataIC50: 1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552475(CHEMBL4779271)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552477(CHEMBL4777141)
Affinity DataIC50: 2.15E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552480(CHEMBL4740091)
Affinity DataIC50: 2.52E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50552482(CHEMBL4792819)
Affinity DataIC50: 2.85E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetUbiquitin carboxyl-terminal hydrolase isozyme L5(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM223313(Tiaprofenic acid)
Affinity DataIC50: 2.95E+6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human UCHL5 expressed in Escherichia coli BL21 (DE3) codon cells assessed as reduction in cleavage o...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed