Compile Data Set for Download or QSAR
Report error Found 562 of ic50 data for polymerid = 50004894
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50581154(CHEMBL5090533)
Affinity DataIC50: 100nMAssay Description:Inhibition of human MOF using AcCoA and H4 peptide as substrate incubated for 12 min at room temperature relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653585(US11911372, Example 6 | US20240277683, Example 6)
Affinity DataIC50: 746nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653585(US11911372, Example 6 | US20240277683, Example 6)
Affinity DataIC50: 746nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653656(US11911372, Example 78 | US20240277683, Example 78)
Affinity DataIC50: 768nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653656(US11911372, Example 78 | US20240277683, Example 78)
Affinity DataIC50: 768nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653601(US11911372, Example 22 | US20240277683, Example 22)
Affinity DataIC50: 1.05E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653601(US11911372, Example 22 | US20240277683, Example 22)
Affinity DataIC50: 1.05E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM43339(4-azanylnaphthalen-1-ol;hydrochloride | PCMD-CC-PA...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM646444(US11911372, Example 87 | US11911372, Example 69 | ...)
Affinity DataIC50: 1.21E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM646444(US11911372, Example 87 | US11911372, Example 69 | ...)
Affinity DataIC50: 1.21E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM43339(4-azanylnaphthalen-1-ol;hydrochloride | PCMD-CC-PA...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM43339(4-azanylnaphthalen-1-ol;hydrochloride | PCMD-CC-PA...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653655(US11911372, Example 77 | US20240277683, Example 77)
Affinity DataIC50: 2.03E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653655(US11911372, Example 77 | US20240277683, Example 77)
Affinity DataIC50: 2.03E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653584(US11911372, Example 5 | US20240277683, Example 5)
Affinity DataIC50: 3.96E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653584(US11911372, Example 5 | US20240277683, Example 5)
Affinity DataIC50: 3.96E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653587(US11911372, Example 8 | US20240277683, Example 8)
Affinity DataIC50: 4.03E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653587(US11911372, Example 8 | US20240277683, Example 8)
Affinity DataIC50: 4.03E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653586(US11911372, Example 7 | US20240277683, Example 7)
Affinity DataIC50: 5.12E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653586(US11911372, Example 7 | US20240277683, Example 7)
Affinity DataIC50: 5.12E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM646444(US11911372, Example 87 | US11911372, Example 69 | ...)
Affinity DataIC50: 5.51E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653662(US11911372, Example 84)
Affinity DataIC50: 5.51E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653651(US11911372, Example 73 | US20240277683, Example 73)
Affinity DataIC50: 5.78E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653651(US11911372, Example 73 | US20240277683, Example 73)
Affinity DataIC50: 5.78E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470498(CHEMBL4282866)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470503(CHEMBL4288384)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50282619(CHEMBL4159902)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470501(CHEMBL4290743)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622027(CHEMBL5437016)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653590(US11911372, Example 11 | US20240277683, Example 11)
Affinity DataIC50: 8.84E+3nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653590(US11911372, Example 11 | US20240277683, Example 11)
Affinity DataIC50: 8.84E+3nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM43339(4-azanylnaphthalen-1-ol;hydrochloride | PCMD-CC-PA...)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM606556(US11685732, Compound I-200)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM606664(US11685732, Compound I-308)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM606533(US11685732, Compound I-177)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assay buffer was 50 mM Tris pH 8.0, 0.002% Tween20, 0.005% bovine skin gelatin, and 1 mM dithiothreitol (DTT). For determination of IC50values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653591(US11911372, Example 12 | US20240277683, Example 12)
Affinity DataIC50: 1.03E+4nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653591(US11911372, Example 12 | US20240277683, Example 12)
Affinity DataIC50: 1.03E+4nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622012(CHEMBL5426408)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653588(US11911372, Example 9 | US20240277683, Example 9)
Affinity DataIC50: 1.26E+4nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653588(US11911372, Example 9 | US20240277683, Example 9)
Affinity DataIC50: 1.26E+4nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622026(CHEMBL5436305)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470507(CHEMBL4291382)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622021(CHEMBL5421687)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653640(US11911372, Example 62 | US20240277683, Example 62)
Affinity DataIC50: 1.62E+4nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM653640(US11911372, Example 62 | US20240277683, Example 62)
Affinity DataIC50: 1.62E+4nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622013(CHEMBL5427978)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470506(CHEMBL4280076)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50622024(CHEMBL5410807)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of N-terminal 6His tagged KAT8 (173 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated histone H...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetHistone acetyltransferase KAT8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50470504(CHEMBL4286898)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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