Compile Data Set for Download or QSAR
Report error Found 66 of ic50 data for polymerid = 50004581,50006282
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419064(CHEMBL1823874)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419067(CHEMBL1823878)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419065(CHEMBL1823875)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419068(CHEMBL1823879)
Affinity DataIC50: 50.1nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419069(CHEMBL1823880)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419080(CHEMBL1823677)
Affinity DataIC50: 126nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419053(ZD-7288 | CHEMBL2052019)
Affinity DataIC50: 158nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419070(CHEMBL1823881)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419066(CHEMBL1823876)
Affinity DataIC50: 251nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419085(CHEMBL1823887)
Affinity DataIC50: 316nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688533(US20240190854, Example 9)
Affinity DataIC50: 370nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419074(CHEMBL1823886)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419062(CHEMBL1435630)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419055(CHEMBL1823666)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419083(CHEMBL1823882)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688629(US20240190854, Example 125)
Affinity DataIC50: 400nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688578(US20240190854, Example 73)
Affinity DataIC50: 500nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419060(CHEMBL1823674)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419075(CHEMBL1823888)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419078(CHEMBL1823667)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688577(US20240190854, Example 72)
Affinity DataIC50: 1.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419054(CHEMBL1823665)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688574(US20240190854, Example 69)
Affinity DataIC50: 1.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419084(CHEMBL1823885)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688530(US20240190854, Example 6)
Affinity DataIC50: 1.80E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688568(US20240190854, Example 68 | US20240190854, Example...)
Affinity DataIC50: 2.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688582(US20240190854, Example 77)
Affinity DataIC50: 2.20E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688634(US20240190854, Example 14)
Affinity DataIC50: 2.40E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419076(CHEMBL1823889)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688632(US20240190854, Example 12)
Affinity DataIC50: 2.80E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688639(US20240190854, Example 19)
Affinity DataIC50: 2.90E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688529(US20240190854, Example 5)
Affinity DataIC50: 2.90E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688535(US20240190854, Example 30)
Affinity DataIC50: 3.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688636(US20240190854, Example 16)
Affinity DataIC50: 3.00E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688633(US20240190854, Example 13)
Affinity DataIC50: 3.20E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688620(US20240190854, Example 116)
Affinity DataIC50: 3.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688575(US20240190854, Example 70)
Affinity DataIC50: 3.80E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688644(US20240190854, Example 24)
Affinity DataIC50: 4.20E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688576(US20240190854, Example 71)
Affinity DataIC50: 4.40E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688618(US20240190854, Example 114)
Affinity DataIC50: 4.50E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688579(US20240190854, Example 74)
Affinity DataIC50: 4.60E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688635(US20240190854, Example 15)
Affinity DataIC50: 5.10E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688641(US20240190854, Example 21)
Affinity DataIC50: 5.30E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688638(US20240190854, Example 18)
Affinity DataIC50: 7.60E+3nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688568(US20240190854, Example 68 | US20240190854, Example...)
Affinity DataIC50: 8.00E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688529(US20240190854, Example 5)
Affinity DataIC50: 8.70E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688534(US20240190854, Example 29)
Affinity DataIC50: 8.90E+3nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419087(CHEMBL1823676)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419071(CHEMBL1823883)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM688640(US20240190854, Example 20)
Affinity DataIC50: 1.69E+4nMAssay Description:Sophion Qube Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In DepthDetails
US Patent

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