Compile Data Set for Download or QSAR
Report error Found 1075 of ic50 data for polymerid = 50003206
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His-6-tagged human wild type Eg5 (1 to 368) expressed in Escherichia coli BL21 by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50427294(SB-743921 | CHEMBL2325429)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of MT-stimulated ATPase activity of wild type Eg5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50: 0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50463302(CHEMBL4239814)
Affinity DataIC50: 0.200nMAssay Description:Inhibition EG5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509092(US11071788, Example M4 | S-(1-{2-[2-({(2S)-2-Amino...)
Affinity DataIC50: 0.271nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50: 0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50: 0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220966(1-[(3R,3aR)-8-fluoro-3-(3-morpholin-4-yl-propyl)-3...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509099(US11071788, Example M12 | 4-{[(1R)-2-({2-[(3-Amino...)
Affinity DataIC50: 0.446nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509093(US11071788, Example M5 | (3R,7S)-7-Amino-17-{[(2R)...)
Affinity DataIC50: 0.457nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50: 0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM682022(N-(2-{[(2R)-2-Amino-2-carboxyethyl]sulphanyl}-3-ca...)
Affinity DataIC50: 0.467nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509097(US11071788, Example M10 | (2R,28R)-28-Amino-2-[({2...)
Affinity DataIC50: 0.470nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50181139((S)-2-amino-2-cyclopropyl-1-((S)-4-(2,5-difluoroph...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220958(1-[(3R,3aR)-3-(3-amino-propyl)-8-fluoro-3-phenyl-3...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50181139((S)-2-amino-2-cyclopropyl-1-((S)-4-(2,5-difluoroph...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KSPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM103307(US8546434, 4)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509095(US11071788, Example M7 | S-(2-{[2-({(2S)-2-Amino-4...)
Affinity DataIC50: 0.621nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM34539(US8546434, 13)
Affinity DataIC50: 0.690nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50: 0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM103306(US8546434, 3)
Affinity DataIC50: 0.740nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220324(1-((R)-5-((S)-3-amino-2-fluoropropyl)-3-(2,5-diflu...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509107(US11071788, Example M20 | US11071788, Example M22 ...)
Affinity DataIC50: 0.827nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM103305(US8546434, 2)
Affinity DataIC50: 0.830nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM103309(US8546434, 6)
Affinity DataIC50: 0.830nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM123468(US8748626, 1)
Affinity DataIC50: 0.840nMpH: 7.5 T: 2°CAssay Description:This example provides a representative in vitro assay for determining KSP activity in vitro. Purified microtubules obtained from bovine brain were pu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM34538(US8546434, 12)
Affinity DataIC50: 0.870nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM34536(US8546434, 10)
Affinity DataIC50: 0.900nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220964(1-[3-((3R,3aR)-2-acetyl-8-fluoro-3-phenyl-3a,4-dih...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220326((S)-1-(5-(3-aminopropyl)-3-(2,5-difluorophenyl)-5-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509113(US11071788, Example M26 | 4-[(2-{[2-({(2S)-2-Amino...)
Affinity DataIC50: 0.944nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM103304(US8546434, 1)
Affinity DataIC50: 0.960nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509102(US11071788, Example M15 | 4-[(2-{[2-({(2S)-2-Amino...)
Affinity DataIC50: 0.964nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50: 1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220969(1-{(3R,3aR)-3-[3-(4-acetyl-piperazin-1-yl)-propyl]...)
Affinity DataIC50: 1nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220970(1-[(3R,3aR)-8-methyl-3-(3-morpholin-4-yl-propyl)-3...)
Affinity DataIC50: 1nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220967(1-[(3R,3aR)-8-chloro-3-(3-dimethylamino-propyl)-3-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of kinesin spindle proteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220320(1-((S)-3-(2,5-difluorophenyl)-5-(3-((S)-3-fluoropy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220331(1-((S)-5-(3-((1R,4R)-5-oxa-2-aza-bicyclo[2.2.1]hep...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50220332(1-((S)-5-(3-(2-aza-bicyclo[2.2.1]heptan-2-yl)propy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50353767(CHEMBL1829430)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50353767(CHEMBL1829430)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509096(US11071788, Example M9 | N-(3-Aminopropyl)-N-{(1R)...)
Affinity DataIC50: 1.07nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50330546(4-Furan-6-methyl-N-(4-methoxyphenyl)-4,7-dihydro-2...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509098(US11071788, Example M11 | S-{2-[(3-Aminopropyl){(1...)
Affinity DataIC50: 1.11nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50181138((S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-(3-hyd...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50181138((S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-(3-hyd...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of KSPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50431891(CHEMBL2347651)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM34532(US8546434, 7)
Affinity DataIC50: 1.23nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinesin-like protein KIF11(Human)
The Beatson Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM509110(US11071788, Example M23 | N-{(2S)-2-Amino-4-[{(1R)...)
Affinity DataIC50: 1.26nMAssay Description:The motor domain of the human kinesin spindle protein KSP/Eg5 (tebu-bio/Cytoskeleton Inc, No. 027EG01-XL) was incubated in a concentration of 10 nM w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
US Patent

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