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Report error Found 493 of ic50 data for polymerid = 50001212,50001213
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353115(CHEMBL1829127)
Affinity DataIC50: 0.0680nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353110(CHEMBL1829122)
Affinity DataIC50: 0.0730nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353113(CHEMBL1829125)
Affinity DataIC50: 0.0840nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353114(CHEMBL1829126)
Affinity DataIC50: 0.0910nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353111(CHEMBL1829123)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353097(CHEMBL1829132)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50201454(N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-(pyr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353116(CHEMBL1829128)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353098(CHEMBL1829133)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353103(CHEMBL1829139)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353102(CHEMBL1829138)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378116(CHEMBL1202327)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353105(CHEMBL1829117)
Affinity DataIC50: 1.06nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353099(CHEMBL1829134)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297583(N''-[2-(1H-benzimidazol-2-ylthio)-5-nitro-2,3-dihy...)
Affinity DataIC50: 1.17nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50207580(N-[3-(5-nitro-1H-benzoimidazol-2-yl)-benzoyl]-guan...)
Affinity DataIC50: 1.42nMAssay Description:Inhibition of NHE1 in rat platelets by Platelet swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50353101(CHEMBL1829137)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297577(N''-[2-(1H-benzimidazol-2-ylthio)-2,3-dihydro-1H-i...)
Affinity DataIC50: 1.73nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297571(N''-{2-[(5-nitro-1H-benzimidazol-2-yl)thio]-2,3-di...)
Affinity DataIC50: 1.74nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50345911(CHEMBL1789669 | CHEMBL1783852 | N-(diaminomethylen...)
Affinity DataIC50: 1.82nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297563(N''-[2-(1,3-benzothiazol-2-ylthio)-6-methoxy-2,3-d...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297578(2-{[(1E)-2-(1,3-benzothiazol-2-ylsulfanyl)-4,5,6-t...)
Affinity DataIC50: 1.98nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297580(N''-[2-(1,3-benzothiazol-2-ylthio)-5-chloro-2,3-di...)
Affinity DataIC50: 2.34nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297562(N''-[2-(1,3-benzothiazol-2-ylthio)-5,6-dimethoxy-2...)
Affinity DataIC50: 2.44nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104843(N-[3-(3-Bromo-4-fluoro-phenyl)-2,2-dimethyl-cyclop...)
Affinity DataIC50: 3nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50345911(CHEMBL1789669 | CHEMBL1783852 | N-(diaminomethylen...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of NHE1-mediated rat platelet swellingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50207583(N-[2-(5-nitro-1H-benzoimidazol-2-yl)-benzoyl]-guan...)
Affinity DataIC50: 4.05nMAssay Description:Inhibition of NHE1 in rat platelets by Platelet swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50345917(N-(diaminomethylene)-3-(N-methylsulfamoyl)-4-(1-(4...)
Affinity DataIC50: 4.48nMAssay Description:Inhibition of NHE1-mediated rat platelet swellingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50191852(2-(5-(4-fluoro-3-methylphenyl)-4-(4-(4-methyl-1H-i...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396463(CHEMBL2170611)
Affinity DataIC50: 5nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104846(N-[3-(2,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 5nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104848(N-[3-(3-Ethyl-4-fluoro-phenyl)-2,2-dimethyl-cyclop...)
Affinity DataIC50: 5nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50191839(5-(1-(5-(3-chloro-4-fluorophenyl)pyrimidin-4-yl)pi...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396469(CHEMBL2170610)
Affinity DataIC50: 6nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104856(N-[3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 6nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104856(N-[3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cyclopropa...)
Affinity DataIC50: 6nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50191831(5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-meth...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50191846(5-(4-fluoro-3-methylphenyl)-2-isopropoxy-4-(4-(4-m...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50137552(5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50: 8nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50201465(3-amino-N-(diaminomethylene)-5-(2,5-dichlorophenyl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50201443(N-(diaminomethylene)-5-(2,5-dichlorophenyl)-3-(dim...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396471(CHEMBL2170608)
Affinity DataIC50: 10nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50201470(5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human NHE1 by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50297575(2-{[(1E)-2-(1H-1,3-benzodiazol-2-ylsulfanyl)-4,5,6...)
Affinity DataIC50: 10.8nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50396470(CHEMBL2170609)
Affinity DataIC50: 11nMAssay Description:Inhibition of NHE1 in human HT-29 cells assessed as intracellular pH change after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50207572(N-[4-(5-nitro-1H-benzoimidazol-2-yl)-benzoyl]-guan...)
Affinity DataIC50: 11nMAssay Description:Inhibition of NHE1 in rat platelets by Platelet swelling assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50345908(N-(diaminomethylene)-2-((4-(2,3,4-trimethoxybenzyl...)
Affinity DataIC50: 11.1nMAssay Description:Inhibition of NHE1-mediated rat platelet swellingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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