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TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515773(US11053225, Compound 23)
Affinity DataIC50: 0nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515786(US11053225, Compound 69)
Affinity DataIC50: 0.120nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384584(CHEMBL2036807 | US9744172, Compound UNC607A)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384583(CHEMBL2036806)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515821(US11053225, Compound 102)
Affinity DataIC50: 0.360nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350865(US9795606, B26 | UNC1667A | US10004755, Compound U...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308226(US9649309, Compound UNC4103A)
Affinity DataIC50: 0.430nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308193(US9649309, Compound UNC2571A)
Affinity DataIC50: 0.470nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308186(US9649309, Compound UNC2550A)
Affinity DataIC50: 0.490nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM628988(N-{3-fluoro-4-[(2-{[2-(4-methanesulfonylpiperazin-...)
Affinity DataIC50: 0.5nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350848(US9795606, B7 | UNC2078A | US10004755, Compound UN...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308189(US9649309, Compound UNC2547A)
Affinity DataIC50: 0.560nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50055498(CHEMBL3326004 | US9795606, B28 | US10004755, Compo...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM628989(N-{3-fluoro-4-[(2-{[2-(pyrrolidin-1-yl)pyrimidin-4...)
Affinity DataIC50: 0.600nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308318(US9649309, Compound UNC3667A)
Affinity DataIC50: 0.610nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308188(US9649309, Compound UNC2489A)
Affinity DataIC50: 0.630nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308349(US9649309, Compound UNC4160A)
Affinity DataIC50: 0.670nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50444070(CHEMBL3092795)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50444072(CHEMBL3092793)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308181(US9649309, Compound UNC2432A)
Affinity DataIC50: 0.690nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308201(US9649309, Compound UNC2606A)
Affinity DataIC50: 0.690nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50444073(CHEMBL3092792)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350844(US9795606, B3 | UNC1972A | US10004755, Compound UN...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350843(US9795606, B2 | UNC1971A | US10004755, Compound UN...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50384582(CHEMBL2036805)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308194(US9649309, Compound UNC2572A)
Affinity DataIC50: 0.760nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515836(US11053225, Compound 137)
Affinity DataIC50: 0.780nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50563635(CHEMBL4777640)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50201078(CHEMBL3964573)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of MerTK (unknown origin) by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM50444068(CHEMBL3092797)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308192(US9649309, Compound UNC2546A)
Affinity DataIC50: 0.810nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308354(US9649309, Compound UNC4169A)
Affinity DataIC50: 0.810nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515783(US11053225, Compound 65)
Affinity DataIC50: 0.820nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308229(US9649309, Compound UNC4162A)
Affinity DataIC50: 0.830nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308198(US9649309, Compound UNC2251B)
Affinity DataIC50: 0.840nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308351(US9649309, Compound UNC4167A)
Affinity DataIC50: 0.860nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350851(US9795606, B10 | UNC2123A | US10004755, Compound U...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515806(US11053225, Compound 115)
Affinity DataIC50: 0.900nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM497276((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM515798(US11053225, Compound 100)
Affinity DataIC50: 0.910nMAssay Description:For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM350850(US9795606, B9 | UNC2095A | US10004755, Compound UN...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM401001(US10004755, Compound UNC2396A)
Affinity DataIC50: 0.930nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase Mer(Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM308317(US9649309, Compound UNC3666A)
Affinity DataIC50: 0.940nMAssay Description:Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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