Compile Data Set for Download or QSAR
Report error Found 56 of ic50 data for polymerid = 50000457,50004788,50007455
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Affinity DataIC50: 27nMpH: 6.7Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50348098(CHEMBL1800430)
Affinity DataIC50: 224nMAssay Description:Inhibition of ASIC1aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408492(CHEMBL5269133)
Affinity DataIC50: 407nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408498(CHEMBL5270983)
Affinity DataIC50: 518nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408502(CHEMBL5289168)
Affinity DataIC50: 729nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408500(CHEMBL5278611)
Affinity DataIC50: 972nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408497(CHEMBL5287933)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408493(CHEMBL5285672)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408496(CHEMBL5291421)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50157090(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408495(CHEMBL5267130)
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408499(CHEMBL5276647)
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408494(CHEMBL5267106)
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Affinity DataIC50: 7.34E+3nMpH: 5.0Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Human)
Bogomoletz Institute of Physiology of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50408501(CHEMBL5283083)
Affinity DataIC50: 9.54E+3nMAssay Description:Inhibition of human ASIC1a in HEK293 cells assessed as inward proton-gated current at pH 6.0 incubated with compound followed by PcTx1 addition by pa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510046(CHEMBL4440380)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510045(CHEMBL4587871)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510047(CHEMBL4517411)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510048(CHEMBL4442568)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510037(CHEMBL4463769)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510036(CHEMBL4555958)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510054(CHEMBL4445209)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510053(CHEMBL4591499)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510051(CHEMBL4527919)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510049(CHEMBL4590631)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510052(CHEMBL4446500)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510056(CHEMBL4450681)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510050(CHEMBL4463485)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510055(CHEMBL4440787)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510057(CHEMBL4538655)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510044(CHEMBL4462808)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510034(CHEMBL4593063)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510035(CHEMBL4528810)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510038(CHEMBL4518161)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510039(CHEMBL4456021)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510040(CHEMBL4469611)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510041(CHEMBL4476781)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510042(CHEMBL4593172)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510043(CHEMBL4524195)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-car...)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAcid-sensing ion channel 1(Mouse)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50: 5.69E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50074922(2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | ...)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250133(Butibufen)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169044((2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid | ...)
Affinity DataIC50: 2.88E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcid-sensing ion channel 1(Rat)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50: 3.47E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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