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TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | WO-2014/19...)
Affinity DataIC50: 0.372nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM669513(US20240131013, Compound C)
Affinity DataIC50: 1.35nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50503111(CHEMBL4528514 | US11672785, Goodacre Compound 102 ...)
Affinity DataIC50: 1.62nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50169743(CHEMBL1358 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50169743(CHEMBL1358 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9...)
Affinity DataIC50: 2.29nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM605421(US11672785, Compound B | US20240131013, Compound B)
Affinity DataIC50: 2.69nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataIC50: 2.82nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50212166(7-chloro-6H-chromeno[4,3-b]quinoline-3,9-diol | CH...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50212173(7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol | CHE...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50171724(4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol | 4-bro...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501982(CHEMBL4533857)
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501984(CHEMBL4578651)
Affinity DataIC50: 4.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50171726(4-chloro-2-(4-hydroxyphenyl)quinolin-6-ol | 4-Chlo...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501969(CHEMBL4440692)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276796(CHEMBL4170306)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501980(CHEMBL4467767)
Affinity DataIC50: 5.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501986(CHEMBL4543370)
Affinity DataIC50: 5.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501985(CHEMBL4445475)
Affinity DataIC50: 5.70nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501971(CHEMBL4514580)
Affinity DataIC50: 5.70nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]E2 from human recombinant ERalpha receptor after overnight incubation by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501973(CHEMBL4444248)
Affinity DataIC50: 6nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50212172(3,9-dihydroxy-6H-chromeno[4,3-b]quinoline-7-carbon...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501975(CHEMBL4456486)
Affinity DataIC50: 6.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501979(CHEMBL4521251)
Affinity DataIC50: 7nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501974(CHEMBL4461157)
Affinity DataIC50: 7.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501978(CHEMBL4532018)
Affinity DataIC50: 7.70nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276803(CHEMBL4169272)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276805(CHEMBL4166492)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276818(CHEMBL4161346)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501981(CHEMBL4218019)
Affinity DataIC50: 8nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276817(CHEMBL4159613)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276834(CHEMBL4163909)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501983(CHEMBL4538025)
Affinity DataIC50: 9.30nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM19459(Prunetol | Genisteol | CHEMBL44 | US8552057, 2 | c...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ERalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501970(CHEMBL4461263)
Affinity DataIC50: 11nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276816(CHEMBL4166832)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501977(CHEMBL4469374)
Affinity DataIC50: 12nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50336739(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276822(CHEMBL4165363)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501976(CHEMBL4570799)
Affinity DataIC50: 13nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276811(CHEMBL4172522)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276830(CHEMBL4172209)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50336759(4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-meth...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276814(CHEMBL4163054)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276795(CHEMBL4163375)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276835(CHEMBL4173278)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276823(CHEMBL4177113)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50276836(CHEMBL4173757)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50501972(CHEMBL4443118)
Affinity DataIC50: 20nMAssay Description:Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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