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TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50: 11nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50: 11nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50: 12nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50: 12nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50: 21nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50: 21nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 22nMAssay Description:Inhibition of EAAT1 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human EAAT1 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptakeMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50: 31nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50: 31nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410456(CHEMBL2113122)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410463(CHEMBL2113115)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50632378(CHEMBL5423219)
Affinity DataIC50: 116nMAssay Description:Inhibition of human EAAT1 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 120nMAssay Description:Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410457(CHEMBL2113112)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410455(CHEMBL2113116)
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410464(CHEMBL2113111)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410450(CHEMBL2113118)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50173936(2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410451(CHEMBL1628570)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410459(CHEMBL2113117)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50196924(CHEMBL3960774)
Affinity DataIC50: 316nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50196924(CHEMBL3960774)
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197048(CHEMBL3975687)
Affinity DataIC50: 350nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197048(CHEMBL3975687)
Affinity DataIC50: 363nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561803(CHEMBL4790691)
Affinity DataIC50: 370nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561803(CHEMBL4790691)
Affinity DataIC50: 372nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197057(CHEMBL3974720)
Affinity DataIC50: 380nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197057(CHEMBL3974720)
Affinity DataIC50: 380nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410465(CHEMBL2113113)
Affinity DataIC50: 400nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50328509(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50328509(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366637(CHEMBL4164207)
Affinity DataIC50: 620nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366637(CHEMBL4164207)
Affinity DataIC50: 631nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 660nMAssay Description:Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 660nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 660nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50292997(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Affinity DataIC50: 660nMAssay Description:Inhibition of EAAT1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in [14C]glutamate uptake incubated for 5 mins by microbet...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50173917(2-Amino-N-(10-ethyl-10H-phenoxazin-2-yl)-succinami...)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410461(CHEMBL2113126)
Affinity DataIC50: 700nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561801(CHEMBL4759043)
Affinity DataIC50: 708nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561801(CHEMBL4759043)
Affinity DataIC50: 710nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197054(CHEMBL3937517)
Affinity DataIC50: 794nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197026(CHEMBL3909952)
Affinity DataIC50: 794nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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