Compile Data Set for Download or QSAR
Report error Found 2000 of ic50 data for polymerid = 49000505,49000506,50002385,50002666,50004701
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155245(CHEMBL3774897)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50208985(CHEMBL3885244)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]endothelin-1 from human recombinant ETB receptor expressed in CHO cells measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043326(c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-Lys-Gln-c(Cys-V...)
Affinity DataIC50: 0.0930nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197953(CHEMBL3980643)
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataIC50: 0.120nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.140nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043322(c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp-Lys-Gln-Cys)-V...)
Affinity DataIC50: 0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368776(CHEMBL1790962)
Affinity DataIC50: 0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.200nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.200nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.200nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataIC50: 0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50395673(CHEMBL2165327)
Affinity DataIC50: 0.208nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50289647(Compound RES-701-1(1-10)/[A15]ET-1 | CHEMBL263855)
Affinity DataIC50: 0.240nMAssay Description:Binding activity to ET-B receptor on bovine cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368772(CHEMBL2373291)
Affinity DataIC50: 0.25nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.280nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.320nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.320nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368774(CHEMBL1790963)
Affinity DataIC50: 0.330nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197955(CHEMBL1515091)
Affinity DataIC50: 0.410nMAssay Description:Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368777(CHEMBL2373292)
Affinity DataIC50: 0.420nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043324(c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp-Lys-Gln-Cys)-V...)
Affinity DataIC50: 0.450nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.470nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061085((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.480nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.600nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080623((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,2-dimethy...)
Affinity DataIC50: 0.710nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080589((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 0.800nMAssay Description:Functional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 0.810nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051385(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-cyclopropyl-...)
Affinity DataIC50: 0.810nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.830nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.850nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.850nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50532579(CHEMBL4451582)
Affinity DataIC50: 0.860nMAssay Description:Displacement of 125I-ET1 from pig ETB receptor transfected in grivet COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50532579(CHEMBL4451582)
Affinity DataIC50: 0.860nMAssay Description:Displacement of 125I-ET1 from pig ETB receptor transfected in grivet COS7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080628((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,2-dimethy...)
Affinity DataIC50: 0.940nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.980nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.980nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Rat)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105048(N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-m...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Rat)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50107561(N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-2-(2-h...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Rat)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50107562(N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-2-(4-h...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080597((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080597((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080619((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(di-o-tolylm...)
Affinity DataIC50: 1.10nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080616((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2-ethyl-1-p...)
Affinity DataIC50: 1.10nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50051385(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-cyclopropyl-...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards Endothelin B receptor in human girardi heart cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061085((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 1.12nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Pig)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061093((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 1.20nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080593((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080588((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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