Compile Data Set for Download or QSAR
Report error Found 60 of ic50 data for polymerid = 488,50003602,50004917,50007028
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277775((3R,4R)-3-(4-(3,5-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277776((3R,4R)-3-(4-(3,4-dimethylphenoxy)phenyl)-1-oxo-2-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277814((3R,4R)-2-(cyclopropylmethyl)-1-oxo-3-(4-phenoxyph...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277887((3R,4R)-3-(benzo[d]thiazol-2-yl)-2-(2-ethylbutyl)-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277853((3R,4R)-3-(3,4-dichlorophenyl)-2-(2-ethylbutyl)-1-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277728((3R,4R)-3-(4-((cis)-4-methylcyclohexyloxy)phenyl)-...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344068(rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)p...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277729((3R,4R)-2-ethyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344071(rac-3-(4-(4-cyanonaphthalen-1-yloxy)phenyl)hex-4-y...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277852((3R,4R)-3-(3,4-dichlorophenyl)-2-((S)-2-methylbuty...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344084(rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluoromethy...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277888((3R,4R)-3-(benzofuran-2-yl)-2-((S)-2-methylbutyl)-...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344069(rac-3-(4-(2-chloro-4-cyanophenoxy)phenyl)hex-4-yno...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344078(rac-3-(4-(2-p-tolyl-4,5,6,7-tetrahydrobenzo[d]thia...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277777((3R,4R)-1-oxo-2-propyl-3-(4-(5-(trifluoromethyl)py...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344073(rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344070(rac-3-(4-(2-bromo-4-cyanophenoxy)phenyl)hex-4-ynoi...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344067(rac-3-(4-(2-methyl-4-(trifluoromethyl)phenoxy)phen...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344077(3-(4-((R)-2,3-dihydro-1H-inden-1-yloxy)phenyl)hex-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344080(rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)p...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277849((3R,4R)-3-(3,4-dichlorophenyl)-1-oxo-2-propyl-1,2,...)
Affinity DataIC50: 89nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277774((3R,4R)-3-(4-(benzyloxy)phenyl)-1-oxo-2-propyl-1,2...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277851((3R,4R)-3-(benzofuran-2-yl)-1-oxo-2-propyl-1,2,3,4...)
Affinity DataIC50: 119nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 151nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277813((3R,4R)-2-methyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4...)
Affinity DataIC50: 156nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196326(CHEMBL3904654)
Affinity DataIC50: 174nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344072(rac-3-(4-(4-(trifluoromethyl)naphthalen-1-yloxy)ph...)
Affinity DataIC50: 211nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277850((3R,4R)-3-(3-chlorophenyl)-1-oxo-2-propyl-1,2,3,4-...)
Affinity DataIC50: 228nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344079(rac-3-(4-(cyclopentyloxy)phenyl)hex-4-ynoic acid |...)
Affinity DataIC50: 312nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344076(rac-3-(4-(isoquinolin-1-yloxy)phenyl)hex-4-ynoic a...)
Affinity DataIC50: 342nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344074(rac-3-(4-(5-bromopyrimidin-2-yloxy)phenyl)hex-4-yn...)
Affinity DataIC50: 433nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196400(CHEMBL3979588)
Affinity DataIC50: 617nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277730((3R,4R)-3-(4-methoxyphenyl)-1-oxo-2-propyl-1,2,3,4...)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human GPR40 expressed HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344085(trans-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluor...)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196395(CHEMBL3958418)
Affinity DataIC50: 2.46E+3nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344075(rac-3-(4-(3-cyanopyrazin-2-yloxy)phenyl)hex-4-ynoi...)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232256(N-(3-phenoxybenzyl)-4-nitrobenzamide | CHEMBL25507...)
Affinity DataIC50: 2.80E+3nMAssay Description:Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196399(CHEMBL3932897)
Affinity DataIC50: 2.88E+3nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196407(CHEMBL3923955)
Affinity DataIC50: 3.39E+3nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344081(cis-rac-2-(4-(2-chloro-4-(trifluoromethyl)phenoxy)...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196324(CHEMBL3945213)
Affinity DataIC50: 3.89E+3nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344083(rac-5-(1-(4-(benzyloxy)phenyl)but-2-ynyl)oxazolidi...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232261(3-(4-nitrophenoxy)-N-phenylbenzamide | CHEMBL43816...)
Affinity DataIC50: 5.30E+3nMAssay Description:Antagonist activity at FFAR1 expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50143047(CHEMBL3758511)
Affinity DataIC50: 6.30E+3nMAssay Description:Modulation of FFAR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50412913(CHEMBL448569)
Affinity DataIC50: 7.90E+3nMAssay Description:Modulation of FFAR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196405(CHEMBL3931570)
Affinity DataIC50: 8.13E+3nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196410(CHEMBL3913640)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50344082(trans-rac-2-(4-(2-chloro-4-(trifluoromethyl)phenox...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196406(CHEMBL3893258)
Affinity DataIC50: 1.07E+4nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFree fatty acid receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196404(CHEMBL3894632)
Affinity DataIC50: 1.29E+4nMAssay Description:Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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