Compile Data Set for Download or QSAR
Report error Found 41 of ic50 data for polymerid = 3666
LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50012060(CHEMBL3263640)
Affinity DataIC50: 213nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM30178(Pyrrolopyridine, 9)
Affinity DataIC50: 660nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM50315888(N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50582077(CHEMBL5085753)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of MAPKAPK3 (unknown origin) by Z-lyte assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human MAPKAPK3 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM558858(US11370770, Compound 6j)
Affinity DataIC50: 2.30E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 2.90E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of human MAPKAPK3 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50305006(5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-i...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM558866(US11370770, Compound 6r)
Affinity DataIC50: 4.10E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM50220232((S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-...)
Affinity DataIC50: 4.52E+3nMAssay Description:Activity against human MAPK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50583520(CHEMBL5094006)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant MAPKAPK3 expressed in Sf9 insect cells using [KKLNRTLSVA] as substrate in presence of [33P]-ATP by radiometric hotspo...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM558865(US11370770, Compound 6q)
Affinity DataIC50: 5.50E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 6.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM558864(US11370770, Compound 6p)
Affinity DataIC50: 8.50E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50429867(CHEMBL2333365)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50499634(CHEMBL3741589)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK3 (unknown origin)More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50509949(CHEMBL4475216 | US11667631, Example 29)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM50001733(CHEMBL3133821)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MAPKAPK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MAPKAPK3 (2 to end residues) using KKLNRTLSVA as substrate incubated for 40 mins in presence of [gamma-33ATP by radio...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MAPKAPK3 using [KKLNRTLSVA] as substrateMore data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM558867(US11370770, Compound 6s)
Affinity DataIC50: 1.20E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM558848(US11370770, Compound 6a)
Affinity DataIC50: 1.60E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM558880(US11370770, Compound 6ee)
Affinity DataIC50: 2.10E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM93224(Kinase inhibitor, A1)
Affinity DataIC50: 2.10E+4nMAssay Description:Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of recombinant His-tagged human full length MAPKAPK3 expressed in baculovirus expression system using Ser/Thr-04 peptide as substrate afte...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM558850(US11370770, Compound 6b)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAPK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAPK3More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataIC50: 5.77E+4nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50215481(5-methoxy-9,12-diazatetracyclo[10.2.1.0^{2,10}.0^{...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50215497(5-methoxy-9,12-diazatetracyclo[10.3.1.0^{2,10}.0^{...)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50215483(6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed