Compile Data Set for Download or QSAR
Report error Found 1024 of ic50 data for polymerid = 3430,7150,7885,49000060,49000065,49000066,50000955
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50587586(CHEMBL5078731)
Affinity DataIC50: 0.120nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at recombinant human 5-HT2C expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50251647(1H-indole-3-carboxylic acid[6-(2-chloro-pyridin-3-...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50351324(CHEMBL1818901)
Affinity DataIC50: 0.530nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50086065(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM674467(N-(2-(6-chloro-7-deuteromethoxy-naphthalen-1-yl)et...)
Affinity DataIC50: 0.770nMAssay Description:The test tubes were placed under a reaction condition of 25° C. 50 μg of the receptor membrane protein 5-HT2C was added to all the tubes. In non...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50587585(CHEMBL5077004)
Affinity DataIC50: 0.900nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403975(CHEMBL315772)
Affinity DataIC50: 1nMAssay Description:Binding affinity against 5-HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403975(CHEMBL315772)
Affinity DataIC50: 1nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403974(CHEMBL84931)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at recombinant human 5-HT2C expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM85098(N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-y...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5HT2C receptor expressed in HEK293 cells measured after 120 mins by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM85098(N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-y...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]mesuleregine from human recombinant 5-HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50251648(N-(6-(pyridin-3-yloxy)pyridin-3-yl)-1H-indole-3-ca...)
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity against human 5HT2C receptor by GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50251613(6-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50451023(MESULERGINE)
Affinity DataIC50: 1.90nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50260599(CHEMBL4094825)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50587584(CHEMBL5071818)
Affinity DataIC50: 2.70nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50587587(CHEMBL5085055)
Affinity DataIC50: 2.80nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 2C receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50010594(ISOCLOZAPINE | 2-Chloro-11-(4-methyl-piperazin-1-y...)
Affinity DataIC50: 2.90nMAssay Description:Binding affinity towards 5-HT2C receptor from rat using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403978(CHEMBL85735)
Affinity DataIC50: 3nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50060681((6aR,9R)-4,7-Dimethyl-4,6,6a,7,8,9-hexahydro-indol...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50383092(CHEMBL2031574)
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403964(R-95292 | CHEMBL310183)
Affinity DataIC50: 3.80nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403984(CHEMBL82635)
Affinity DataIC50: 3.90nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50324886(naphthalene-2-sulfonic acid isopropyl-[3-(4-methyl...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C expressed in CHOKI cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50333551(2-ethyl-5-(N-methyl-piperazin-1-yl)-1-(naphthalene...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor expressed in cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001775(cid_5074 | Ritanserine | 6-(2-{4-[Bis-(4-fluoro-ph...)
Affinity DataIC50: 4.5nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50251611(5-methyl-N-(6-(2-methylpyridin-3-yloxy)pyridin-3-y...)
Affinity DataIC50: 4.5nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50035179(S 20098 | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-...)
Affinity DataIC50: 4.52nMAssay Description:The test tubes were placed under a reaction condition of 25° C. 50 μg of the receptor membrane protein 5-HT2C was added to all the tubes. In non...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403992(CHEMBL84081)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403991(CHEMBL315834)
Affinity DataIC50: 5nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403969(CHEMBL83731)
Affinity DataIC50: 5.60nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50251645(N-(6-(pyridin-2-ylmethoxy)pyridin-3-yl)-1H-indole-...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]mesulergine at human cloned 5HT2C receptor expressed in CHOK1 cellMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50324861(Naphthalene-2-sulfonicacid cyclopropylmethyl-[3-(4...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C expressed in CHOKI cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50539540(CHEMBL4644910)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor (unknown origin) by cell based radioligand competitive binding analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403976(CHEMBL314107)
Affinity DataIC50: 6.20nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403977(CHEMBL85155)
Affinity DataIC50: 6.30nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells by [3H]mesulergine displacement.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50324863(Naphthalene-2-sulfonic acid [3-(4-methyl-piperazin...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C expressed in CHOKI cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 7nMAssay Description:Antagonistic activity at 5-HT2c receptor (unknown origin) after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50086051(5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-c...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human 5HT2c receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium influx measured up to 30 secs by aequorin ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 7nMAssay Description:Antagonistic activity at 5-HT2c receptor (unknown origin) after 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50403962(CHEMBL81485)
Affinity DataIC50: 7.10nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataIC50: 7.30nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM31005(MIANSERIN HYDROCHLORIDE | SMR000058472 | MLS000069...)
Affinity DataIC50: 7.40nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 2C receptor expressed in CHO cells using [3H]mesulergine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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