Compile Data Set for Download or QSAR
Report error Found 1752 of ic50 data for polymerid = 3387,50001156,50001300,50006504,50007204
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450347(CHEMBL431940)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466752(CHEMBL4281138)
Affinity DataIC50: 3nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182852(US9149492, Compound 1D)
Affinity DataIC50: 3.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182851(US9149492, Compound 1C)
Affinity DataIC50: 3.60nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051895(2-(2,4-Dioxa-spiro[5.5]undec-3-yl)-4,5-diphenyl-1H...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50298278(N-(4-Amino-2,6-diisopropylphenyl)-N'-{[1-[3-(3-hyd...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182849(US9149492, Compound 1A)
Affinity DataIC50: 4.20nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051903(2-[1,3]Dioxolan-2-yl-4,5-diphenyl-1H-imidazole | C...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051461(N-(2,6-Diisopropyl-phenyl)-2-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175766(1-(1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1...)
Affinity DataIC50: 5.40nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038923(1-[4-(2-Chloro-phenyl)-6,7-dimethyl-quinolin-3-yl]...)
Affinity DataIC50: 5.80nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051466(N-(2,6-Diisopropyl-phenyl)-2-(5-dodecyl-tetrazol-2...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285881(12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against acyl-CoA:cholesterol O-acyltransferase (ACAT)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Mouse)
Kowa

Curated by ChEMBL
LigandPNGBDBM50462683(CHEMBL4247249)
Affinity DataIC50: 7nMAssay Description:Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50462683(CHEMBL4247249)
Affinity DataIC50: 7nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037663(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037666(3-(2,4-Difluoro-phenyl)-1-[8-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063243(N-(2,6-Diisopropyl-phenyl)-2-pyridin-2-yl-malonami...)
Affinity DataIC50: 8nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175771(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038906(1-[8-Chloro-4-(2-chloro-phenyl)-6-methyl-quinolin-...)
Affinity DataIC50: 8.90nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050356(2,2-Dimethyl-dodecanoic acid (5-dimethylamino-2,2,...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50466740(CHEMBL4282905)
Affinity DataIC50: 9nMAssay Description:Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50041735(1-(2,6-Diisopropyl-phenyl)-3-[1-(4-dimethylamino-p...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human SOAT1 expressed in mouse AC29 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038918(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Affinity DataIC50: 9.20nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038900(1-(7-Chloro-6-methyl-4-o-tolyl-quinolin-3-yl)-3-(2...)
Affinity DataIC50: 9.30nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) in rat hepatic microsomes by using AIV assay.More data for this Ligand-Target Pair
In DepthDetails

TargetSterol O-acyltransferase 1(Mouse)
Kowa

Curated by ChEMBL
LigandPNGBDBM50450346(CHEMBL300883)
Affinity DataIC50: 10nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell cultureMore data for this Ligand-Target Pair
In DepthDetails

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051456(N-(2,6-Diisopropyl-phenyl)-2-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50: 10nMAssay Description:Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...More data for this Ligand-Target Pair
In DepthDetails

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037622(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037638(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037664(3-Cyclohexyl-1-[5-(4,5-diphenyl-1H-imidazol-2-ylsu...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051456(N-(2,6-Diisopropyl-phenyl)-2-(2-dodecyl-2H-tetrazo...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 of liver microsomes isolated from cholesterol-fed rats.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM50051894(1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 activity obtaine...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063239(N-(2,6-Diisopropyl-phenyl)-2-phenyl-malonamic acid...)
Affinity DataIC50: 10nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033969(3-(2,4-Difluoro-phenyl)-1-[5-(4,5-diphenyl-1H-imid...)
Affinity DataIC50: 10nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
Kowa

Curated by ChEMBL
LigandPNGBDBM182850(US9149492, Compound 1B)
Affinity DataIC50: 10.3nMAssay Description:Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033960(N-{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-yls...)
Affinity DataIC50: 11nMAssay Description:Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063226(N-(2,6-Diisopropyl-phenyl)-2-phenyl-malonamic acid...)
Affinity DataIC50: 11nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50280419(2-[3-(1-Methyl-1H-imidazole-2-sulfonyl)-propylsulf...)
Affinity DataIC50: 11nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175772(SM-32504 | 1-(1-butyl-4-(3-methoxyphenyl)-2-oxo-1,...)
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Chinese hamster)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 12nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from hamster liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038922(1-(2,4-Difluoro-phenyl)-3-(6,8-dimethyl-4-o-tolyl-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038920(1-[6-Chloro-4-(2-chloro-phenyl)-8-methyl-quinolin-...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063231(N-(2,6-Diisopropyl-phenyl)-2-phenyl-malonamic acid...)
Affinity DataIC50: 12nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSterol O-acyltransferase 1(Rat)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063236(N-(2,6-Diisopropyl-phenyl)-2-phenyl-malonamic acid...)
Affinity DataIC50: 12nMAssay Description:In vitro Acyl coenzyme A:cholesterol acyltransferase inhibition in hepatic microsomes isolated from cholesterol-fed ratsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 1752 total ) | Next | Last >>
Jump to: