Compile Data Set for Download or QSAR
Report error Found 317 of ic50 data for polymerid = 3017
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | CHEMBL449129 ...)
Affinity DataIC50: 6nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 17.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)
Affinity DataIC50: 30.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50249793(3',3'',5',5''-tetrabromophenolphthalein | CHEMBL52...)
Affinity DataIC50: 33nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)
Affinity DataIC50: 48nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)
Affinity DataIC50: 76.3nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427621(CHEMBL2323490 | US9346803, 1)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50293598(2'-des-methyl indomethacin | CHEMBL503179 | US9346...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427626(CHEMBL2323481 | US9346803, Table 2, Compound 5: 2-...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427625(CHEMBL178687 | US9346803, Table 2, Compound 6: 3-[...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427629(CHEMBL179587 | US9346803, Table 2, Compound 7: 2-[...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427628(CHEMBL2323472 | US9346803, Table 2, Compound 8: 2-...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427627(CHEMBL2323474 | US9346803, Table 2, Compound 9: 2-...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50330427(5-Chloro-4-hydroxybiphenyl-3-carboxylic acid | CHE...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50330426(5-Fluoro-4-hydroxybiphenyl-3-carboxylic acid | CHE...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466729(CHEMBL4293881)
Affinity DataIC50: 411nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466730(CHEMBL4291554)
Affinity DataIC50: 433nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466716(CHEMBL4287291)
Affinity DataIC50: 443nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50219490(5-bromo-4-hydroxybiphenyl-3-carboxylic acid | 3-Br...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant 20-alpha HSD expressed in BAEC assessed as inhibition of progesterone metabolism treated 2 hrs before progesterone ch...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50219490(5-bromo-4-hydroxybiphenyl-3-carboxylic acid | 3-Br...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human AKR1C1-mediated progesterone metabolism expressed in bovine aortic endothelial cells assessed as formation of 20alpha-hydroxyprog...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466720(CHEMBL4294478)
Affinity DataIC50: 462nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50595596(CHEMBL5203670)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells assessed as inhibition of NADP+ dependent oxi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466717(CHEMBL4294539)
Affinity DataIC50: 487nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466710(CHEMBL4290064)
Affinity DataIC50: 531nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466714(CHEMBL4282842)
Affinity DataIC50: 534nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466724(CHEMBL4287863)
Affinity DataIC50: 661nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataIC50: 700nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396696(CHEMBL2172064)
Affinity DataIC50: 730nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396716(CHEMBL2172091)
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM22971(Meclofenamate | CHEMBL509 | 2-[(2,6-dichloro-3-met...)
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466732(CHEMBL4286627)
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466713(CHEMBL4295234)
Affinity DataIC50: 801nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466739(CHEMBL4279383)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396669(CHEMBL2172108)
Affinity DataIC50: 830nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466733(CHEMBL4280914)
Affinity DataIC50: 844nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466735(CHEMBL4286233)
Affinity DataIC50: 870nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50241817(CHEMBL4081954)
Affinity DataIC50: 950nMAssay Description:Inhibition of recombinant human AKR1C1 using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataIC50: 980nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466711(CHEMBL4290009)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466719(CHEMBL4279326)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50623997(CHEMBL5412756)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466715(CHEMBL4293449)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466734(CHEMBL4278318)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466708(CHEMBL4277845)
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50067678(17-Acetoxy-6alpha-methylprogesterone | 17alpha-Hyd...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant AKR1C1 expressed in Escherichia coli assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotome...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50074922(2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | ...)
Affinity DataIC50: 2.05E+3nMAssay Description:Inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50623996(CHEMBL5421222)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of human recombinant AKR1C1 transfected in Escherichia coli BL21 (DE3) pLysS competent cells using S-tetralol as substrate assessed as inh...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50249792(3,5-Dibromosalicylic acid | CHEMBL447448)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of 20-alpha HSDMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50466731(CHEMBL1510262)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of recombinant human AKR1C1 expressed in Escherichia coli BL21 cells in presence of 9,10-phenanthrenequinone and NADPH by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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