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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569315(US11427563, Compound 70)
Affinity DataIC50: 0.100nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569239(US11427563, Compound 116 | US11427563, Compound 10...)
Affinity DataIC50: 0.200nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569295(US11427563, Compound 49)
Affinity DataIC50: 0.200nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569298(US11427563, Compound 62 | US11427563, Compound 53)
Affinity DataIC50: 0.200nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336163(8-[(5-Chloro-2-{4-[(1-methyl-1H-pyrazol-4-yl)methy...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336181(1-(4-{[3-Carbamoyl-1-(4-fluorophenyl)-4,5-dihydro-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336172(8-(5-chloro-2-(4-hydroxypiperidin-1-yl)isonicotina...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336173(8-(5-chloro-2-(2-methoxyethylamino)isonicotinamido...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569251(US11427563, Compound 120 | US11427563, Compound 11...)
Affinity DataIC50: 0.600nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569268(US11427563, Compound 85 | US11427563, Compound 7 |...)
Affinity DataIC50: 0.600nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569304(US11427563, Compound 78 | US11427563, Compound 59)
Affinity DataIC50: 0.600nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569268(US11427563, Compound 85 | US11427563, Compound 7 |...)
Affinity DataIC50: 0.600nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal His-tagged recombinant IKK2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336193(8-{[2-(4-{[1-(2-Amino-2-oxoethyl)-1H-pyrazol-4-yl]...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336176(Ethyl [4-({4-[4-({[3-(aminocarbonyl)-1-(4-fluoroph...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336199(8-[(5-Chloro-2-{4-[(1-{2-[(2-hydroxyethyl)amino]-2...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336190(Methyl [4-({4-[4-({[3-(aminocarbonyl)-1-(4-fluorop...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336170(8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinam...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336191(2-methoxyethyl 2-(4-((4-(4-(3-carbamoyl-1-(4-fluor...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336197(8-[(5-Chloro-2-{4-[(1-{2-[(2-methoxyethyl)amino]-2...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336194(8-({5-Chloro-2-[4-({1-[2-(methylamino)-2-oxoethyl]...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50308585(8-{[5-Chloro-2-(4-methylpiperazin-1-yl)isonicotino...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50308590(8-({5-Chloro-2-[4-(2-methoxyethyl)piperazin-1-yl]i...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336183(8-({5-Chloro-2-[4-(1H-pyrazol-4-ylmethyl)piperazin...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336195(7.12.6. 8-({5-Chloro-2-[4-({1-[2-(isopropylamino)-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336169(8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinam...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336188(8-{[5-Chloro-2-(4-{[1-(3-hydroxypropyl)-1H-pyrazol...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336196(8-({5-Chloro-2-[4-({1-[2-(dimethylamino)-2-oxoethy...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336198(8-{[5-Chloro-2-(4-{[1-(2-{[2-(methylthio)ethyl]ami...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM25933(N-(2-aminoethyl)-12-methyl-4-(1H-pyrrol-2-yl)-3-th...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569331(US11427563, Compound 17 | US11427563, Compound 87)
Affinity DataIC50: 2.70nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336168(8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinam...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336179(8-(5-chloro-2-(4-((1,5-dimethyl-1H-pyrazol-4-yl)me...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336186(8-{[5-Chloro-2-(4-{[1-(3-methoxypropyl)-1H-pyrazol...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM25960(amino-N-({3-[12-methyl-8-(methylamino)-3-thia-1,7,...)
Affinity DataIC50: 3nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50149846(2''-Amino-6''-(2-cyclopropylmethoxy-6-hydroxy-phen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336174(8-[(5-Chloro-2-{4-[(1-methyl-1H-pyrazol-4-yl)methy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50149846(2''-Amino-6''-(2-cyclopropylmethoxy-6-hydroxy-phen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human IKK-beta using TMB as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50149846(2''-Amino-6''-(2-cyclopropylmethoxy-6-hydroxy-phen...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM25960(amino-N-({3-[12-methyl-8-(methylamino)-3-thia-1,7,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336201(8-{[5-Chloro-2-(4-{[1-(2-{[3-(dimethylamino)propyl...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336167(8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinam...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336180(8-[(5-Chloro-2-{(3S)-3-methyl-4-[(1-methyl-1Hpyraz...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569268(US11427563, Compound 85 | US11427563, Compound 7 |...)
Affinity DataIC50: 3.60nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336189(8-({5-Chloro-2-[4-({1-[3-(dimethylamino)propyl]-1H...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50336182(4-(4-{[3-Carbamoyl-1-(4-fluorophenyl)-4,5-dihydro-...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant IKK2 in human PBMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50395536(CHEMBL2164412)
Affinity DataIC50: 3.98nMAssay Description:Inhibition of IKK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50149839(2''-Amino-6''-(2-cyclobutylmethoxy-6-hydroxy-pheny...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human I-kappa-B-kinase beta (IKK beta)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50149839(2''-Amino-6''-(2-cyclobutylmethoxy-6-hydroxy-pheny...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human IKK-beta using TMB as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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