Compile Data Set for Download or QSAR
Report error Found 804 of ic50 data for polymerid = 2271,49000494,50001848
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021208(CHEMBL545671 | [3-(4-Bromo-phenyl)-indan-1-yl]-met...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026953((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...)
Affinity DataIC50: 0.300nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021208(CHEMBL545671 | [3-(4-Bromo-phenyl)-indan-1-yl]-met...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021230(CHEMBL545201 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021230(CHEMBL545201 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021235(CHEMBL554756 | CHEMBL51224 | [3-(4-Chloro-phenyl)-...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021220(CHEMBL555549 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021220(CHEMBL555549 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021242(CHEMBL553590 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021214(CHEMBL537996 | CHEMBL300019 | [3-(3,4-Dichloro-phe...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021217(Talsupram | CHEMBL52247 | [3-(3,3-Dimethyl-1-pheny...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50127384(3-(3-Fluoro-4-methyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50168041(3-(3-Fluoro-4-methyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021225(CHEMBL542850 | [3-(3,4-Difluoro-phenyl)-indan-1-yl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021225(CHEMBL542850 | [3-(3,4-Difluoro-phenyl)-indan-1-yl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021245(CHEMBL301782 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021224((+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]...)
Affinity DataIC50: 2.5nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataIC50: 2.60nMAssay Description:Norepinephrine transporter activity was determined by the ability of compound to inhibit the neurotransmitter norepinephrine-NE reuptake system using...More data for this Ligand-Target Pair
In DepthDetails Article

TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021246(3-(3,3-dimethyl-1-phenyl-1,3-dihydroisobenzofuran-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021222(CHEMBL53837 | [3-(3,4-Dichloro-phenyl)-6-methoxy-i...)
Affinity DataIC50: 3nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021222(CHEMBL53837 | [3-(3,4-Dichloro-phenyl)-6-methoxy-i...)
Affinity DataIC50: 3nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM35226(Vestra | Reboxetine | (S,S)-reboxetine)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 4.10nMAssay Description:In vitro inhibitory activity against radioligand [3H]-nisoxatine binding to norepinephrine transporter (NET) in rat cortical tissueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50168044(3-(3,5-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50168042(3-(4-Fluoro-3-methyl-phenyl)-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50: 4.23nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021247(CHEMBL300069 | [3-(4-Bromo-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021247(CHEMBL300069 | [3-(4-Bromo-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021238(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021238(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50275774(N,N-Diallyl (1R,2R)-2-(Aminomethyl)-1-(2-thienyl)c...)
Affinity DataIC50: 4.60nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50207752([(1S,2R)-2-(diethylcarbamoyl)-2-(naphthalen-2-yl)c...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]5-HT uptake at NE transporter in Wistar rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 5.40nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 5.41nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 5.45nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50041282((3S,8R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of [3H]nisoxetine binding to norepinephrine (NE) transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021221(CHEMBL542117 | [3-(2,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021221(CHEMBL542117 | [3-(2,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021213(CHEMBL301514 | 1-(3,4-Dichloro-phenyl)-3-methylami...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50168047(3-(3,4-Difluoro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021213(CHEMBL301514 | 1-(3,4-Dichloro-phenyl)-3-methylami...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
University of Urbino

Curated by ChEMBL
LigandPNGBDBM50239791((1S,2R)-N-allyl-2-(aminomethyl)-N-ethyl-1-(thiophe...)
Affinity DataIC50: 6.40nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from rat synaptosomal NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50005548((+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquin...)
Affinity DataIC50: 6.60nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50021218(CHEMBL51697 | 2-Methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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