Compile Data Set for Download or QSAR
Report error Found 9728 of ic50 data for polymerid = 2262,6274,8608,8894,49000426,50000634,50001226,50001411,50004637
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50: 0.0692nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50: 0.0800nMAssay Description:Tested in vitro for inhibition against Prostaglandin G/H synthase 2 in human blood (95% confidence limits)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.120nMAssay Description:Tested in vitro for inhibition against Prostaglandin G/H synthase 2 in human blood (95% confidence limits)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by colorimetric assa...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.141nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272128(N-(4-(3-phenyl-1H-indol-2-yl)phenylsulfonyl)acetam...)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272128(N-(4-(3-phenyl-1H-indol-2-yl)phenylsulfonyl)acetam...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM315131(US10172814, Example 74 | (2R/S)-3-[3-({(2R/S)-2-[4...)
Affinity DataIC50: 0.188nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50365267(CHEMBL1958349)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50297677(N-benzyl-4-(4-(methylsulfonyl)phenyl)-6-(trifluoro...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50297675(N-(4-fluorobenzyl)-4-(4-(methylsulfonyl)phenyl)-6-...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272130(5-methyl-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272130(5-methyl-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.282nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50100403({3-[4-(4-Bromo-phenyl)-thiazol-2-ylmethyl]-5-metho...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50373567(CHEMBL271173)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272111(5-chloro-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272111(5-chloro-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.363nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272124(3-(4-bromophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272124(3-(4-bromophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-...)
Affinity DataIC50: 0.372nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50373588(CHEMBL270293)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human COX2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50153990(4-[2-(4-Ethoxy-phenyl)-pyrazolo[1,5-b]pyridazin-3-...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50057527(4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50056998(Meloxicam sodium | 4-Hydroxy-2-methyl-1,1-dioxo-1,...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate and measured by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50029613(1-methoxy-4-[2-(4-methylsulfonylphenyl)-1-cyclopen...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50297669(N-cyclohexyl-4-(4-(methylsulfonyl)phenyl)-6-(trifl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272090(4-(5-chloro-3-(4-chlorophenyl)-1H-indol-2-yl)benze...)
Affinity DataIC50: 0.537nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272090(4-(5-chloro-3-(4-chlorophenyl)-1H-indol-2-yl)benze...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50317931((2R*,3S*,4R*,6S*)-2-(4-Chlorophenyl)-6-((ethylthio...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of ovine COX2 assessed as inhibition of PGF2a formation after 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50272106(2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-indole | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.601nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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