Compile Data Set for Download or QSAR
Report error Found 593 of ic50 data for polymerid = 2256
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249294((R)-2-amino-2-(4-(4-(5-phenylpentyloxy)phenyl)-1H-...)
Affinity DataIC50: 1.23nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147714(Phosphoric acid mono-[2-amino-4-(4-octyl-phenyl)-b...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)
Affinity DataIC50: 1.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataIC50: 2.20nMAssay Description:Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 2.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315559((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)-3-(trif...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50: 3.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249114((S)-2-amino-2-methyl-3-oxo-3-(4-(5-phenylpentyloxy...)
Affinity DataIC50: 3.60nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)
Affinity DataIC50: 4nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249240((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylam...)
Affinity DataIC50: 4.17nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315562((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)-3-(trif...)
Affinity DataIC50: 4.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249266((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-...)
Affinity DataIC50: 4.87nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249266((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-...)
Affinity DataIC50: 4.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249263((S)-2-amino-3-(4-(3-(biphenyl-4-yl)propoxy)phenyla...)
Affinity DataIC50: 5.24nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249154((S)-2-amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino...)
Affinity DataIC50: 6.15nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50: 6.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249153((S)-2-amino-3-(4-(4-cyclohexylbutoxy)phenylamino)-...)
Affinity DataIC50: 8.30nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152322({2-[5-(4-Nonyl-phenyl)-pyrrolidin-2-yl]-ethyl}-pho...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152322({2-[5-(4-Nonyl-phenyl)-pyrrolidin-2-yl]-ethyl}-pho...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249113((S)-2-amino-2-methyl-3-oxo-3-(4-(4-phenylbutoxy)ph...)
Affinity DataIC50: 10.3nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249240((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylam...)
Affinity DataIC50: 10.3nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249293((R)-2-amino-2-(4-(4-(4-phenylbutoxy)phenyl)-1H-imi...)
Affinity DataIC50: 11.7nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50315550((S)-2-amino-3-(4-(3-(biphenyl-4-yl)propanoyl)pheny...)
Affinity DataIC50: 13.1nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23163({2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propo...)
Affinity DataIC50: 15nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148399(Phosphoric acid mono-[1-amino-1-hydroxymethyl-3-(4...)
Affinity DataIC50: 15nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152337(2-amino-2-({[dihydroxy(oxido)--phosphanyl]oxy}meth...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147703(CHEMBL115554 | CHEMBL115713 | [(1S,3R)-3-Amino-1-h...)
Affinity DataIC50: 16nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147703(CHEMBL115554 | CHEMBL115713 | [(1S,3R)-3-Amino-1-h...)
Affinity DataIC50: 16nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344797(5-(2,5-dichlorophenyl)-N-(4-(hydroxymethyl)-2,6-di...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147713([3-Amino-1-hydroxy-5-(4-octyl-phenyl)-pentyl]-phos...)
Affinity DataIC50: 23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148391({3-[2-(4-Octyl-phenyl)-ethylamino]-propyl}-phospho...)
Affinity DataIC50: 24nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249264((S)-2-amino-3-(4-(4-(biphenyl-4-yl)butoxy)phenylam...)
Affinity DataIC50: 24.8nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344799(N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dich...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249265((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)pheny...)
Affinity DataIC50: 26.9nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50152328([(1S,3S)-3-(4-Nonyl-benzylamino)-cyclohexyl]-phosp...)
Affinity DataIC50: 32nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148434([3-(3-Bromo-5-methoxy-4-nonyloxy-benzylamino)-prop...)
Affinity DataIC50: 33nMAssay Description:Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50: 34nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344798(4-(5-(2,5-dichlorophenyl)furan-2-carboxamido)-3,5-...)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344816(N-(4-(hydroxymethyl)-2,6-dimethylphenyl)-5-(3-meth...)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM62223(SR-01000669308 | cid_1363299 | SR-01000669308-2 | ...)
Affinity DataIC50: 39.3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM22216(1-({4-[5-(4-cyclohexylphenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50: 40nMT: 2°CAssay Description:The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148394([3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid |...)
Affinity DataIC50: 40nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50148394([3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid |...)
Affinity DataIC50: 40nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344813(5-(2,5-dichlorophenyl)-N-(2-ethyl-6-methylphenyl)f...)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Praecis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344803(5-(2,5-dichlorophenyl)-N-(4-(2-hydroxyethoxy)-2,6-...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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