Compile Data Set for Download or QSAR
Report error Found 5551 of ic50 data for polymerid = 2253,2273,49000126,49000128,50003079
LigandPNGBDBM50021219(CHEMBL553648 | [3-(2,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021219(CHEMBL553648 | [3-(2,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataIC50: 0.110nMAssay Description:Inhibitory concentration against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021213(CHEMBL301514 | 1-(3,4-Dichloro-phenyl)-3-methylami...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021213(CHEMBL301514 | 1-(3,4-Dichloro-phenyl)-3-methylami...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.130nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021247(CHEMBL300069 | [3-(4-Bromo-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021247(CHEMBL300069 | [3-(4-Bromo-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124562(1-[3-(4-isopropenylphenyl)-(2S,3S)-8-azabicyclo[3....)
Affinity DataIC50: 0.160nMAssay Description:Binding affinity towards serotonin transporter (SERT) by using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047103(2-{3-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330813(3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50: 0.220nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM264118(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50149945(CHEMBL3770205)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of [3H]paroxetine (0.2 nM) binding to 5-HT transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50021208(CHEMBL545671 | [3-(4-Bromo-phenyl)-indan-1-yl]-met...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021208(CHEMBL545671 | [3-(4-Bromo-phenyl)-indan-1-yl]-met...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047089(2-{3-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047108(2-{2-[4-(6-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50151999(3-{4-[4-(3,4-Dimethoxy-phenyl)-piperazin-1-yl]-but...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]5-HT re-uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50152012(5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]5-HT re-uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50152027(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [3H]5-HT re-uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50152012(5-{4-[4-(5-Fluoro-1H-indol-3-yl)-butyl]-piperazin-...)
Affinity DataIC50: 0.300nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50278521((S)-N-butyl-N-(naphthalen-2-ylmethyl)pyrrolidin-3-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM84745(DULOXETINE | LY-248686 | CAS_136434-34-9 | LY24868...)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124569(1-[3-(4-vinylphenyl)-(2S,3S)-8-azabicyclo[3.2.1]oc...)
Affinity DataIC50: 0.320nMAssay Description:Binding affinity towards serotonin transporter (SERT) by using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294(trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopen...)
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50616408(CHEMBL5420565)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of SERT receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50021238(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209166(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole-5-c...)
Affinity DataIC50: 0.340nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021238(CHEMBL50635 | [3-(4-Chloro-phenyl)-indan-1-yl]-dim...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50246181(1-(2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmeth...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of serotonin reuptake at SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50616410(CHEMBL5431204)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of SERT receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124565(methyl 3-(4-iodophenyl)-(2S,3S)-8-azabicyclo[3.2.1...)
Affinity DataIC50: 0.360nMAssay Description:Binding affinity towards serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50: 0.360nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50: 0.360nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50453639(CHEMBL2112889)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of [3H]paroxetine binding to 5-hydroxytryptamine (5-HT) transporterMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021245(CHEMBL301782 | [3-(3,4-Dichloro-phenyl)-indan-1-yl...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50021228(CHEMBL53635 | 1-(3,4-Dichloro-phenyl)-3-dimethylam...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330844(3-[(1R,3S)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50: 0.380nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047092(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50047100(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50151988(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [3H]5-HT re-uptake in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SERT (unknown origin) expressed in HEK293 cells assessed as reduction in 5-HT uptake incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50151988(3-{4-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pipera...)
Affinity DataIC50: 0.400nMAssay Description:inhibition of rat cerebral 5HT transporter assessed as reduction in [3H]5HT reuptake after 4 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SERT (unknown origin) in HEK293 cells assessed as inhibition of 5-HT reuptake by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent serotonin transporter(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SERT (unknown origin) expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
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