Compile Data Set for Download or QSAR
Report error Found 1537 of ic50 data for polymerid = 2225,3609,50001944
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205961(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205952(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205910(methyl (3S)-3-{2-[(1,3-benzodioxol-5-ylmethyl)amin...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205937(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205950(2-((R)-1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)pyrro...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205947(N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZO...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205911(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205932(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205956(N-(1,3-benzodioxol-5-ylmethyl)-1-[6-chloro-2-(1H-i...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205905(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205957(N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205926(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205954(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205907((2R)-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-1-(6-et...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205973(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205938(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205909(N-(1,3-benzodioxol-5-ylmethyl)-4-(2-furanylcarbony...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205968(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205930(2-((R)-4-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205904(1-[2-(1H-imidazol-1-yl)-4-pyrimidinyl]-N-[(4-metho...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205971(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205964(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205965(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205931(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50096347(CHEMBL224752)
Affinity DataIC50: 1nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205920(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205921(3-[2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205929(4-(acetyl)-N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205924(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205974(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205976(N-[(1,3-benzodioxol-5-yl)methyl]-4-[(5-dimethylami...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50111448(N-Benzo[1,3]dioxol-5-ylmethyl-2-[1-(6-chloro-2-imi...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205953(3-[2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethy...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205903(1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[(3,4-dim...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant iNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205955(N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205980(N-[(1,3-benzodioxol-5-yl)methyl]hexahydro-1-[2-(1H...)
Affinity DataIC50: 2nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50124519(5,8-Difluoro-2-furan-2-yl-1,2-dihydro-quinazolin-4...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM331831(US10189791, CDDO-Im 1)
Affinity DataIC50: 2nMAssay Description:Because oxidative and inflammatory stress contribute to carcinogenesis (Albini & Sporn (2007) Nature Rev. Cancer 7:139-147), it was determined whethe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205914(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataIC50: 3nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205944(N-[(4-fluorophenyl)methyl]-1-[2-(1H-imidazol-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205940(1-[2-(1H-imidazol-1-yl)-4-pyrimidinyl]-N-[2-(4-met...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205970(1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[(3-metho...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50339998((R)-2-(3-amino-1-phenylpropylthio)-4-chlorobenzoni...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50340003((R)-2-(3-amino-1-phenylpropylthio)-6-methylnicotin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50205939(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-1...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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