Compile Data Set for Download or QSAR
Report error Found 1013 of ic50 data for polymerid = 2142,49000104,49000107,49000109
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328390(US9663498, Example 30 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.0660nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328384(US9663498, Example 24 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.0740nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328391(US9663498, Example 31 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0850nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328394(US9663498, Example 34 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328397(US9663498, Example 40 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.0900nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328396(US9663498, Example 39 | 6-chloro-1-((3-(4-cyclopro...)
Affinity DataIC50: 0.0920nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328392(US9663498, Example 32 | 3-(difluoromethyl)-6-chlor...)
Affinity DataIC50: 0.100nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328395(US9663498, Example 37 | 6-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.130nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328380(US9663498, Example 20 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328400(US9663498, Example 45 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.140nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328381(US9663498, Example 21 | 6-bromo-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.170nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156203(CHEMBL3781299)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328388(US9663498, Example 28 | 3-(difluoromethyl)-5-bromo...)
Affinity DataIC50: 0.200nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328379(US9663498, Example 19 | 6-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.210nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328386(US9663498, Example 26 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.220nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM111790(US8618114, 1.2.22(5).HCl)
Affinity DataIC50: 0.227nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328401(US9663498, Example 46 | 3-(difluoromethyl)-1-((3-(...)
Affinity DataIC50: 0.25nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328389(US9663498, Example 29 | 3-(difluoromethyl)-6-fluor...)
Affinity DataIC50: 0.260nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156201(CHEMBL3781323)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM111771(US8618114, 1.2.11(1))
Affinity DataIC50: 0.293nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156209(CHEMBL3780579)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328393(US9663498, Example 33 | 3-(difluoromethyl)-6-bromo...)
Affinity DataIC50: 0.330nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50417932(CHEMBL1668587 | US8618114, 1.2.4(1))
Affinity DataIC50: 0.340nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50158027(4-[5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-i...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328399(US9663498, Example 44 | 3-(difluoromethyl)-1-((4-m...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328402(US9663498, Example 47 | 1-((3-(4-cyclopropylpipera...)
Affinity DataIC50: 0.400nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328366(US9663498, Example 6 | 4-fluoro-1-((4-methoxy-3-(4...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328408(US9663498, Example 58 | 5-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328412(US9663498, Example 71 | 6-chloro-3-ethyl-1-((4-met...)
Affinity DataIC50: 0.450nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328383(US9663498, Example 23 | 3-(difluoromethyl)-5-fluor...)
Affinity DataIC50: 0.460nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156226(CHEMBL3781452)
Affinity DataIC50: 0.460nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328398(US9663498, Example 41 | 6-chloro-1-((3-(4-cyclobut...)
Affinity DataIC50: 0.5nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156199(CHEMBL3779904)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328404(US9663498, Example 49 | 5,6-dichloro-3-(difluorome...)
Affinity DataIC50: 0.540nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328387(US9663498, Example 27 | 5-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.550nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM111787(US8618114, 1.2.22(2).HCl)
Affinity DataIC50: 0.560nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328382(US9663498, Example 22 | 7-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.570nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328407(US9663498, Example 57 | 6-bromo-3-(difluoromethyl)...)
Affinity DataIC50: 0.580nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328362(US9663498, Example 2 | 1-((4-methoxy-3-(4-methylpi...)
Affinity DataIC50: 0.590nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50169599(CHEMBL194307 | CHEMBL187865 | 1-Benzenesulfonyl-3-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cAMP production in HeLa cells expressing human 5-HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328413(US9663498, Example 72 | 6-bromo-3-ethyl-1-((4-meth...)
Affinity DataIC50: 0.600nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328411(US9663498, Example 70 | 3-ethyl-6-fluoro-1-((4-met...)
Affinity DataIC50: 0.630nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328385(US9663498, Example 25 | 5-chloro-3-(difluoromethyl...)
Affinity DataIC50: 0.640nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM111788(US8618114, 1.2.22(3).HCl)
Affinity DataIC50: 0.645nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM111785(US8618114, 1.2.22(1).HCl)
Affinity DataIC50: 0.670nMAssay Description:Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328378(US9663498, Example 18 | 6-fluoro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.670nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM328409(US9663498, Example 60 | 5-chloro-1-((4-methoxy-3-(...)
Affinity DataIC50: 0.670nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50156200(CHEMBL3780274)
Affinity DataIC50: 0.690nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50139789({3-[2-(3-Bromo-phenyl)-1H-indol-3-yl]-propyl}-dime...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition against human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM50158048(1-(2-Chloro-benzenesulfonyl)-3-(1-methyl-1,2,3,6-t...)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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