Compile Data Set for Download or QSAR
Report error Found 975 of ic50 data for polymerid = 2135,5538,49000144,49000168,49000169,50001973,50004628,50005740,50006955
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataIC50: 0.0229nMAssay Description:Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50318267(4-methoxy-N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]p...)
Affinity DataIC50: 0.0610nMAssay Description:Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataIC50: 0.0977nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117223(5-Butyl-8-(4-methoxy-phenyl)-3H-[1,2,4]triazolo[5,...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity for human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50138568(CHEMBL3754229)
Affinity DataIC50: 0.110nMAssay Description:Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50397727(CHEMBL2181968)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117222(5-Butyl-8-(4-ethoxy-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 0.210nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117214(5-Butyl-8-(3-methoxy-phenyl)-3H-[1,2,4]triazolo[5,...)
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117234(8-Phenyl-5-propyl-3H-[1,2,4]triazolo[5,1-i]purine ...)
Affinity DataIC50: 0.230nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117231(5-Butyl-8-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117232(5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine |...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117232(5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine |...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117232(5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine |...)
Affinity DataIC50: 0.25nMAssay Description:Binding affinity for human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117226(5-Butyl-8-m-tolyl-3H-[1,2,4]triazolo[5,1-i]purine ...)
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117217(5-Butyl-8-(2-chloro-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 0.290nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117228(5-Pentyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine ...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117216(5-Butyl-8-(4-propoxy-phenyl)-3H-[1,2,4]triazolo[5,...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117225(5-Butyl-8-p-tolyl-3H-[1,2,4]triazolo[5,1-i]purine ...)
Affinity DataIC50: 0.330nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117237(5,8-Diphenyl-3H-[1,2,4]triazolo[5,1-i]purine | CHE...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117238(5-Butyl-8-(4-chloro-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117238(5-Butyl-8-(4-chloro-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 0.410nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117220(5-Ethyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine |...)
Affinity DataIC50: 0.450nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 0.490nMAssay Description:Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50224352(4-methoxy-N-(1-oxo-2-p-tolyl-1H-3,3,5,9b-tetraaza-...)
Affinity DataIC50: 0.580nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I]AB-MECA from human recombinant adenosine receptor A3 expressed in HEK293 cells measured after 120 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I]ABMECA from human recombinant adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117221(5-Hexyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine |...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117215(5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]tri...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [3H]CGS-21680 from human Adenosine A3 receptor expressed in HEK293 cells at 10000 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117215(5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]tri...)
Affinity DataIC50: 0.610nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117215(5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]tri...)
Affinity DataIC50: 0.610nMAssay Description:Binding affinity for human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117215(5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]tri...)
Affinity DataIC50: 0.610nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117239([4-(5-Butyl-3H-[1,2,4]triazolo[5,1-i]purin-8-yl)-p...)
Affinity DataIC50: 0.670nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117108(4-[3-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2...)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against Human Adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117109(1-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimula...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50318268(N-(2-methyl-6-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4...)
Affinity DataIC50: 0.740nMAssay Description:Antagonist activity at adenosine A3 receptor in human U87MG cells assessed as inhibition of Cl-IB-MECA-mediated ERK1/2 phosphorylation after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50149106(8-Biphenyl-4-yl-5-(2-methoxy-ethyl)-3H-[1,2,4]tria...)
Affinity DataIC50: 0.900nMAssay Description:Displacement of specific [125I]AB-MECA binding at human adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 0.933nMAssay Description:Antagonist activity at wild type A3R (unknown origin) expressed in Flp-In-CHO cells assessed as inhibition of NECA reduced forskolin stimulated cAMP ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117230(5-Methyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine ...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50323040(1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylamin...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]AB-MECA from human recombinant A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50138715(CHEMBL3753642)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human A3 receptor expressed in CHO cells assessed as inhibition of Cl-IB-MECA-induced cAMP production by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50300278((1'S,2'R,3'S,4'S,5'S)-4'-[6-(3-Chlorobenzylamino)-...)
Affinity DataIC50: 1.09nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production tre...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117227(5-Butyl-8-(3-chloro-phenyl)-3H-[1,2,4]triazolo[5,1...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117236(5-Butyl-8-(3,4,5-trimethoxy-phenyl)-3H-[1,2,4]tria...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at wild type human A3 receptor stably expressed in Flp-In CHO cells cotransfected with pOG44 assessed as inhibition of forskolin-ind...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at human Adenosine A3 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50341607(1-benzyl-3-(4-oxo-3-phenyl-3,4-dihydrophthalazin-1...)
Affinity DataIC50: 1.15nMAssay Description:Antagonist activity at human cloned adenosine A3 receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation after 15 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117233(5-Butyl-8-(4-tert-butyl-phenyl)-3H-[1,2,4]triazolo...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50117242(5-Butyl-8-pyridin-3-yl-3H-[1,2,4]triazolo[5,1-i]pu...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]AB-MECA binding to human Adenosine A3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50118812(CHEMBL119709 | (3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-io...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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