Compile Data Set for Download or QSAR
Report error Found 6259 of ic50 data for polymerid = 2071,6342,50003368,50004763
LigandPNGBDBM50492805(CHEMBL2414497)
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50264967((2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)p...)
Affinity DataIC50: 0.0690nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM642078(US11845730, Example 9-peak-1)
Affinity DataIC50: 0.0900nMAssay Description:Assay buffer preparation: 1 HBSS, 2 mM HEPES, 0.1% BSA plus 2.5 mM freshly prepared probenecid (Invitrogen, #P36400). 25 μl/well assay buffer in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM369799(US10233177, Example 51)
Affinity DataIC50: 0.100nMAssay Description:Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM20315(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)
Affinity DataIC50: 0.110nMAssay Description:Antagonist activity at TRPV1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM369798(US10233177, Example 48)
Affinity DataIC50: 0.130nMAssay Description:Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50492808(CHEMBL2414501)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50492809(CHEMBL2414498)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM642142(US11845730, Example 69)
Affinity DataIC50: 0.150nMAssay Description:Assay buffer preparation: 1 HBSS, 2 mM HEPES, 0.1% BSA plus 2.5 mM freshly prepared probenecid (Invitrogen, #P36400). 25 μl/well assay buffer in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at human brain TRPV1 expressed in HEK293T cells assessed as inhibition of CAP-induced intracellular Ca2+ influx by fluorescence-b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50418189(CHEMBL1761696)
Affinity DataIC50: 0.158nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50492805(CHEMBL2414497)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.180nMAssay Description:Antagonist activity against human TRPV1 expressed in T-REx HEK cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ accum...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50323836(3-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluor...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human TRPV1 assessed as inhibition of capsaicin-induced receptor activation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50315610((4-Trifluoromethylphenyl)-[7-(3-trifluoromethylpyr...)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50315616(3-[3-(Trifluoromethyl)pyridin-2-yl]-N-[5-(trifluor...)
Affinity DataIC50: 0.230nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsazepine-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataIC50: 0.270nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK cells assessed as inhibition of 10 nM capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50566150(CHEMBL4781687)
Affinity DataIC50: 0.270nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin induced intracellular Ca2+ ions by fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50492806(CHEMBL2414504)
Affinity DataIC50: 0.290nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of temperature-induced calcium flux after 30 mins by Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM20531(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Affinity DataIC50: 0.300nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50261646((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...)
Affinity DataIC50: 0.300nMpH: 5.0Assay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of pH 5 acid-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272889(2-(isopropoxymethyl)-N-(4-(trifluoromethyl)phenyl)...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50261646((R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-...)
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50492807(CHEMBL2414502)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50492808(CHEMBL2414501)
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at rat TRPV1 receptor expressed in HEK293T cells assessed as inhibition of capsaicin-induced calcium flux after 30 mins by Fluo-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50264925((S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)py...)
Affinity DataIC50: 0.360nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM210894(US9273043, A123(e))
Affinity DataIC50: 0.400nMpH: 7.2 T: 2°CAssay Description:pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM210898(US9273043, A126(e))
Affinity DataIC50: 0.400nMpH: 7.2 T: 2°CAssay Description:pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50191713(N-(4-tert-butylphenyl)-4-[3-(N-methanesulfonylmeth...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity against low pH(5.0-5.5)-activated rat VR1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50170047((4-Hydroxy-3-iodo-5-methoxy-phenyl)-acetic acid (2...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of 100 nM capsaicin effect on intracellular [Ca2+] concentration in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272976(2-((2,6-dimethylmorpholino)methyl)-N-(4-(trifluoro...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50241325(N-(4-(2-(1-isobutyl-1,2,3,6-tetrahydropyridin-4-yl...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM642176(US11845730, Example 103)
Affinity DataIC50: 0.440nMAssay Description:Assay buffer preparation: 1 HBSS, 2 mM HEPES, 0.1% BSA plus 2.5 mM freshly prepared probenecid (Invitrogen, #P36400). 25 μl/well assay buffer in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50621014(CHEMBL5406113)
Affinity DataIC50: 0.460nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin induced intracellular Ca2+ ions by fluor...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
LigandPNGBDBM50265041(N-(4-(6-(2-(1-(pyridin-2-yl)ethylamino)-4-(trifluo...)
Affinity DataIC50: 0.480nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20557(N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl...)
Affinity DataIC50: 0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20557(N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl...)
Affinity DataIC50: 0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM185339(US9156830, I-7)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50272890(2-(benzyloxymethyl)-N-(4-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272850(2-(methoxymethyl)-N-(4-(trifluoromethyl)phenyl)-7-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 receptor assessed as inhibition of low pH-induced activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20557(N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50133817(BCTC | CHEMBL441472 | N-(4-tert-butylphenyl)-4-(3-...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed as blockade of capsaicin-induced receptor activation by [45Ca2+] uptake assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50254419(N2-(2,6-dichlorophenyl)-N7-(4-(pyrrolidin-1-ylsulf...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50272848(2-methyl-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifl...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50254080((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Displayed 1 to 50 (of 6259 total ) | Next | Last >>
Jump to: