Compile Data Set for Download or QSAR
Report error Found 341 of ic50 data for polymerid = 1733,4481
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605782(CHEMBL5174953)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605748(CHEMBL5206328)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605781(CHEMBL5202475)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175745(7-(1-tert-butylpiperidin-4-yl)-1-(2,6-dichlorophen...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of wild type p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605756(CHEMBL5184542)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605761(CHEMBL5197888)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50605772(CHEMBL5208103)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human full length His-tagged p38beta expressed in baculovirus expression system preincubated for 2 hrs followed by ATP addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16530(N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,...)
Affinity DataIC50: 2nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50: 2nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human p38beta expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50492386(CHEMBL2401979)
Affinity DataIC50: 4nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50492386(CHEMBL2401979)
Affinity DataIC50: 4nMAssay Description:Inhibition of human p38beta expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 7nMAssay Description:Inhibition of P38beta2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50421141(CHEMBL2088578)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071873(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50421140(CHEMBL2088591)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50317579(6-(2,4-difluorophenyl)-1-(2,6-difluorophenyl)-2H-q...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50421137(CHEMBL2088588)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50071867(4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50331622(5-amino-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged P38beta MAPK (1 to 364 residues) expressed in Escherichia coli incubated for 60 mins by [gamma-33P]ATP bas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50505859(CHEMBL4436748)
Affinity DataIC50: 10nMAssay Description:Inhibition of p38-beta (unknown origin) expressed in human HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBR...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50376227(CHEMBL412281)
Affinity DataIC50: 12nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 12nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16524(2-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,...)
Affinity DataIC50: 15nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099349(2-(2,3-Dimethyl-phenoxy)-4-[5-(4-fluoro-phenyl)-3-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50317588(6-(2,4-difluorophenyl)-1-(2-fluoro-5-(5-methyl-1,3...)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50317583(1-(2,6-difluoro-4-(5-methyl-1,3,4-oxadiazol-2-yl)p...)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50556597(CHEMBL4756586)
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal NanoLuc-fused full length p38beta (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50492393(CHEMBL2401978)
Affinity DataIC50: 18nMAssay Description:Inhibition of human p38beta expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM682026(3-(5-(1H-indole-3- carbonyl)pyridin-2-yl)-N- cyclo...)
Affinity DataIC50: 18.8nMAssay Description:Briefly, the compounds were diluted at concentrations of 1000, 333, 111, 37.0, 12.3, 4.12, 1.37, 0.457, 0.152, and 0.0495 nM, respectively, and then ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50348880(CHEMBL1807446)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16525(2-{3-[(2-chloro-4-fluorophenyl)[1-(2-chlorophenyl)...)
Affinity DataIC50: 20nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM682023(N-Cyclopropyl-3-(5-(4-(2,3- dihydroxypropoxy)benzo...)
Affinity DataIC50: 22.3nMAssay Description:Briefly, the compounds were diluted at concentrations of 1000, 333, 111, 37.0, 12.3, 4.12, 1.37, 0.457, 0.152, and 0.0495 nM, respectively, and then ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50361467(CHEMBL1938400)
Affinity DataIC50: 23nMAssay Description:Inhibition of p38beta MAPKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099334(4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50: 25nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50421127(CHEMBL2088582)
Affinity DataIC50: 27nMAssay Description:Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM50122916(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)
Affinity DataIC50: 28nMAssay Description:Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16527(N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,...)
Affinity DataIC50: 29nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16529(N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,...)
Affinity DataIC50: 29nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Mouse)
Merck Research Laboratories

LigandPNGBDBM16528(N-{3-[(2-chlorophenyl)[1-(2-chlorophenyl)-6-oxo-1,...)
Affinity DataIC50: 31nMAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50505859(CHEMBL4436748)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human His-tagged P38beta MAPK (1 to 364 residues) expressed in Escherichia coli incubated for 60 mins by [gamma-33P]ATP bas...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 33.1nMAssay Description:Inhibition of human p38beta using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM682024(6-Chloro-N-cyclopropyl-4'- (1H-indole-3-carbonyl)-...)
Affinity DataIC50: 34.1nMAssay Description:Briefly, the compounds were diluted at concentrations of 1000, 333, 111, 37.0, 12.3, 4.12, 1.37, 0.457, 0.152, and 0.0495 nM, respectively, and then ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM682025(N-Cyclopropyl-3-(5-(6-(2,3- dihydroxypropoxy)-1H-i...)
Affinity DataIC50: 34.3nMAssay Description:Briefly, the compounds were diluted at concentrations of 1000, 333, 111, 37.0, 12.3, 4.12, 1.37, 0.457, 0.152, and 0.0495 nM, respectively, and then ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 11(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50396845(CHEMBL2170294)
Affinity DataIC50: 36nMAssay Description:Inhibition of human MAPK p38beta by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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