Compile Data Set for Download or QSAR
Report error Found 75 of ic50 data for polymerid = 1245,1247
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 4.25nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 4.30nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11419(Compound 17j1 | 2-[(4-Methoxyphenyl)methyl]-3-[(4-...)
Affinity DataIC50: 5.45nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11427(CHEMBL108380 | 5-{[(4-methylphenyl)sulfonyl]amino}...)
Affinity DataIC50: 5.60nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11425(2-(3-hydroxyphenyl)-1,1-dioxo-3-[(prop-2-yn-1-ylam...)
Affinity DataIC50: 6.25nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataIC50: 7.40nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataIC50: 7.41nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11423(Compound 17n1 | 2-[4-(morpholin-4-yl)phenyl]-3-(mo...)
Affinity DataIC50: 8.65nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11422(Compound 17m1 | 2-(3,4-Dimethoxyphenyl)-3-[(4-morp...)
Affinity DataIC50: 10.1nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11394(Compound 5b | 2-[2-(4-Morpholinyl)ethyl]-2H-thieno...)
Affinity DataIC50: 15.2nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11397(2-methyl-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7...)
Affinity DataIC50: 16.9nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11399(Compound 17a7 | 3-{[(2-methoxyethyl)(prop-2-en-1-y...)
Affinity DataIC50: 16.9nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataIC50: 17.5nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317409(5-(Aminosulfonyl)-N-(2-pyridin-2-ylethyl)-2-[(2,3,...)
Affinity DataIC50: 20.9nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50515806(CHEMBL4533252)
Affinity DataIC50: 21nMAssay Description:Inhibition of human carbonic anhydrase 4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317411(5-(Aminosulfonyl)-N-[2-(4-methoxyphenyl)ethyl]-2-[...)
Affinity DataIC50: 23nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317407(5-(Aminosulfonyl)-N-(3-methoxypropyl)-2-[(2,3,5,6-...)
Affinity DataIC50: 23nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317403(5-(Aminosulfonyl)-N-(pyridin-2-ylmethyl)-2-[(2,3,5...)
Affinity DataIC50: 23nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11411(3-(morpholin-4-ylmethyl)-1,1-dioxo-2-(prop-2-en-1-...)
Affinity DataIC50: 23.3nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11416(Compound 17i1 | 2-(3-Methoxypropyl)-3-[(4-morpholi...)
Affinity DataIC50: 23.6nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataIC50: 32nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317410(N-(3-Aminopropyl)-5-(aminosulfonyl)-2-[(2,3,5,6-te...)
Affinity DataIC50: 33.1nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11414(Compound 17h1 | 2-(2-Methoxyethyl)-3-[(4-morpholin...)
Affinity DataIC50: 39.9nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataIC50: 43nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataIC50: 45nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataIC50: 45.3nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317405(5-(Aminosulfonyl)-2-[(3,4-difluorophenyl)thio]-N-(...)
Affinity DataIC50: 46.8nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11413(Compound 17g1 | 2-cyclohexyl-3-(morpholin-4-ylmeth...)
Affinity DataIC50: 49.5nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317402(N-(2-phenylethyl)-2-(phenylsulfanyl)-5-sulfamoylpy...)
Affinity DataIC50: 64nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM10890(E7070 | Sulfonamide, 7 | Compound 6 | CHEMBL77517 ...)
Affinity DataIC50: 65nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11396(2-[2-(Propylamino)ethyl]-2H-thieno[3,2-e]-1,2-thia...)
Affinity DataIC50: 73.6nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317406(5-(Aminosulfonyl)-N-(3-methoxypropyl)-2-[(3-fluoro...)
Affinity DataIC50: 118nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317404(5-(Aminosulfonyl)-N-ethyl-2-[(3-fluorophenyl)thio]...)
Affinity DataIC50: 126nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM11392((4R)-4-amino-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4...)
Affinity DataIC50: 128nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317408(5-(Aminosulfonyl)-2-[(3,4-difluorophenyl)thio]-N-(...)
Affinity DataIC50: 139nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317418(6-[(2,3,5,6-Tetrafluorophenyl)thio]pyridine-3-sulf...)
Affinity DataIC50: 188nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM10881(CHEMBL288100 | cid_4100 | N-[(2Z)-3-methyl-5-sulfa...)
Affinity DataIC50: 205nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317401(5-(Aminosulfonyl)-2-(phenylthio)-N-propylnicotinam...)
Affinity DataIC50: 229nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317386(5-(Aminosulfonyl)-N-benzyl-2-(phenylthio)benzamide...)
Affinity DataIC50: 241nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317400(N-(3-methoxypropyl)-2-(phenylsulfanyl)-5-sulfamoyl...)
Affinity DataIC50: 246nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317397(5-(Aminosulfonyl)-N-ethyl-2-(phenylthio)nicotinami...)
Affinity DataIC50: 283nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 290nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 290nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 340nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Bruker-Axs

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50317399(5-(Aminosulfonyl)-N-(2-methoxyethyl)-2-(phenylthio...)
Affinity DataIC50: 361nMAssay Description:Inhibition of carbonic anhydrase 4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Alcon Research

LigandPNGBDBM50296250((S,Z)-3-(2-hydroxy-5-(1-hydroxy-3-methylbutyl)-4-m...)
Affinity DataIC50: 380nMAssay Description:Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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