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Report error Found 259 of ic50 data for polymerid = 120
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160974([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory concentration against caspase-6 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160957([3-(2-{5-tert-Butyl-3-[(4-methyl-furazan-3-ylmethy...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitory concentration against casp-6 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119267(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10356((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 8nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50340548((4S,7S,10S,13S)-10-sec-butyl-7-(2-carboxyethyl)-13...)
Affinity DataIC50: 8nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50072047(CHEMBL430648 | 4-(2-Acetylamino-3-carboxy-propiony...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119264(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50: 18nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-6 enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50: 37nMAssay Description:Binding affinity towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10356((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 60.5nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10284(4-oxo-4-(piperidin-1-yl)-N-(1,3,4-trioxo-1,2,3,4-t...)
Affinity DataIC50: 124nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10287(N-(2-Methoxy-phenyl)-N-(1,3,4-trioxo-1,2,3,4-tetra...)
Affinity DataIC50: 137nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29578(isatin Michael acceptor (IMA) analogue, 13a)
Affinity DataIC50: 151nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29582(isatin Michael acceptor (IMA) analogue, 18a)
Affinity DataIC50: 156nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29579(isatin Michael acceptor (IMA) analogue, 13b)
Affinity DataIC50: 188nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29583(isatin Michael acceptor (IMA) analogue, 18b)
Affinity DataIC50: 197nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10280(N-(1,3,4-Trioxo-1,2,3,4-tetrahydro-isoquinolin-6-y...)
Affinity DataIC50: 201nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10264(2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50: 216nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29580(isatin Michael acceptor (IMA) analogue, 13c)
Affinity DataIC50: 230nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29585(isatin Michael acceptor (IMA) analogue, 19a)
Affinity DataIC50: 241nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29584(isatin Michael acceptor (IMA) analogue, 18c)
Affinity DataIC50: 280nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10278(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50: 283nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119238(4-Methyl-2-[3-(naphthalen-1-yloxy)-propionylamino]...)
Affinity DataIC50: 305nMAssay Description:Inhibitory concentration required against caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119259(4-Methyl-2-[2-(3-phenoxy-phenylamino)-acetylamino]...)
Affinity DataIC50: 308nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119261(4-Methyl-2-[2-(naphthalen-1-ylamino)-propionylamin...)
Affinity DataIC50: 310nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29572(isatin Michael acceptor (IMA) analogue, 11a)
Affinity DataIC50: 325nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29586(isatin Michael acceptor (IMA) analogue, 19b)
Affinity DataIC50: 358nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50: 407nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29575(isatin Michael acceptor (IMA) analogue, 12a)
Affinity DataIC50: 425nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50117678(CHEMBL3613794)
Affinity DataIC50: 430nMAssay Description:Inhibition of Caspase 6 (1 to 293) C163A mutant (unknown origin) expressed in Escherichia coli BL21-Gold (DE3) assessed as time-resolved luminescence...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50340537((S)-2-(1-(4-methoxybenzyl)-2-oxo-5-(2-((pyridin-3-...)
Affinity DataIC50: 450nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29576(isatin Michael acceptor (IMA) analogue, 12b)
Affinity DataIC50: 453nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29587(isatin Michael acceptor (IMA) analogue, 19c)
Affinity DataIC50: 468nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10247(1,2,3,4-tetrahydroisoquinoline-1,3,4-trione | Isoq...)
Affinity DataIC50: 474nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50340536((S)-2-(1-(4-(2-fluoroethoxy)benzyl)-2-oxo-5-(2-((p...)
Affinity DataIC50: 509nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216418(2-{1-(4-bromo-benzyl)-2-oxo-5-[2-(pyridine-3-yloxy...)
Affinity DataIC50: 515nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29573(isatin Michael acceptor (IMA) analogue, 11b)
Affinity DataIC50: 545nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29574(isatin Michael acceptor (IMA) analogue, 11c)
Affinity DataIC50: 568nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119255(2-[2-(2,3-Diphenyl-propylamino)-acetylamino]-4-met...)
Affinity DataIC50: 589nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM29577(isatin Michael acceptor (IMA) analogue, 12c)
Affinity DataIC50: 592nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50426562(CHEMBL2324339)
Affinity DataIC50: 600nMAssay Description:Inhibition of caspase-6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216419(2-{1-(4-methoxy-benzyl)-2-oxo-5-[2-(pyridin-3-ylox...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216417(2-{1-(4-hydroxy-benzyl)-2-oxo-5-[2-(pyridine-3-ylo...)
Affinity DataIC50: 650nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216420(2-[1-methyl-2-oxo-5-(2-phenoxymethyl-pyrrolidine-1...)
Affinity DataIC50: 698nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50119209(2-[2-(Biphenyl-2-yloxy)-acetylamino]-4-methyl-pent...)
Affinity DataIC50: 717nMAssay Description:Inhibitory concentration required against caspase-6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-6(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50216422(2-[1-(hydroxy-benzyl-2-oxo-5-(2-phenoxymethyl-pyrr...)
Affinity DataIC50: 744nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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