Compile Data Set for Download or QSAR
Report error Found 46 of ic50 data for polymerid = 1197
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM547941(WO2022090481, Example I-162)
Affinity DataIC50: 1.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022090481

LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 1.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481
PDB3D3D Structure (crystal)
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 1.90nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481
PDB3D3D Structure (crystal)
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 2.5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481
PDB3D3D Structure (crystal)
LigandPNGBDBM547965(WO2022090481, Example I-186)
Affinity DataIC50: 2.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481

LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481
PDB3D3D Structure (crystal)
LigandPNGBDBM547940(WO2022090481, Example I-161)
Affinity DataIC50: 3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481

LigandPNGBDBM547983(WO2022090481, Example I-204)
Affinity DataIC50: 3.5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022090481

LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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WIPO WO2022090481

LigandPNGBDBM625598(US20230322822, Compound 14)
Affinity DataIC50: 5.70nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM547888(WO2022090481, Example I-107)
Affinity DataIC50: 7.07nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
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WIPO WO2022090481

LigandPNGBDBM625597(US20230322822, Compound 12)
Affinity DataIC50: 9.80nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625600(US20230322822, Compound 32)
Affinity DataIC50: 10.5nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625596(US20230322822, Compound 11)
Affinity DataIC50: 10.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 13.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625591(US20230322822, Compound 1)
Affinity DataIC50: 19.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625597(US20230322822, Compound 12)
Affinity DataIC50: 29.3nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625594(US20230322822, Compound 6)
Affinity DataIC50: 33.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625591(US20230322822, Compound 1)
Affinity DataIC50: 39.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625599(US20230322822, Compound 24)
Affinity DataIC50: 41.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625599(US20230322822, Compound 24)
Affinity DataIC50: 41.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625595(US20230322822, Compound 9)
Affinity DataIC50: 41.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625598(US20230322822, Compound 14)
Affinity DataIC50: 43.9nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 48.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625593(US20230322822, Compound 5)
Affinity DataIC50: 50nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625594(US20230322822, Compound 6)
Affinity DataIC50: 51nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625600(US20230322822, Compound 32)
Affinity DataIC50: 51.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625610(US20230322822, Compound 30)
Affinity DataIC50: 55.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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US Patent

LigandPNGBDBM625609(US20230322822, Compound 29)
Affinity DataIC50: 57.8nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625605(US20230322822, Compound 13)
Affinity DataIC50: 60.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625596(US20230322822, Compound 11)
Affinity DataIC50: 66.1nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625593(US20230322822, Compound 5)
Affinity DataIC50: 73.7nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625606(US20230322822, Compound 23)
Affinity DataIC50: 79.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625604(US20230322822, Compound 4)
Affinity DataIC50: 80.6nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625608(US20230322822, Compound 28)
Affinity DataIC50: 85.2nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50185235(CHEMBL3823836 | US20230322822, Control compound 2)
Affinity DataIC50: 177nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 178nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM625601(US20230322822, Control compound 1)
Affinity DataIC50: 184nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625603(US20230322822, Control compound 3)
Affinity DataIC50: 203nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625601(US20230322822, Control compound 1)
Affinity DataIC50: 250nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM625603(US20230322822, Control compound 3)
Affinity DataIC50: 250nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50185235(CHEMBL3823836 | US20230322822, Control compound 2)
Affinity DataIC50: 250nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 513nMAssay Description:To assess the effect of compounds on the activity of wild-type and mutant EGFR kinases, kinase activity was tested by measuring ATP consumption in an...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 626nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022090481

LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib |...)
Affinity DataIC50: 745nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails
WIPO WO2022090481