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Report error Found 39 of ic50 data for polymerid = 1159
LigandPNGBDBM527733(5-[1-(cyclopropylmethyl)-2- oxo-1,8-diazaspiro[4.5...)
Affinity DataIC50: 5.40nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527750(5-{3-[2- (dimethylamino)ethyl]-2-oxo- 1-(2,2,2-tri...)
Affinity DataIC50: 7.20nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: 8.90nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527735(5-[1-(cyclopropylmethyl)-2- oxo-1,3,8-triazaspiro[...)
Affinity DataIC50: 9.70nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527736(5-{1-(cyclopropylmethyl)-3- [2-(dimethylamino)ethy...)
Affinity DataIC50: 10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527772(5-[1-(cylcopropylmethyl)-2- oxo-4-oxa-1,8- diazasp...)
Affinity DataIC50: 10nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527754(5-[1-(cyclopropylmethyl)-2,2- dioxido-2-thia-1,3,8...)
Affinity DataIC50: 12nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 16nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527757(5-[1-(cyclopropylmethyl)-3- (2-methoxyethyl)-2-oxo...)
Affinity DataIC50: 18nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527768(5-{1-[(3,3- difluorocyclobutyl)methyl]-2- oxo-1,8-...)
Affinity DataIC50: 18nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527771(5-[1-(cyclobutylmethyl)-2- oxo-3-oxa-1,8- diazaspi...)
Affinity DataIC50: 18nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527777(5-[(3R)-4-{[(1S,2S)-2- fluorocyclopropyl]carbonyl}...)
Affinity DataIC50: 29nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527758(5-[1-(2-methylpropyl)-3-oxo- 2-oxa-4,9- diazaspiro...)
Affinity DataIC50: 30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527770(3-(1-methyl-1H-pyrazol-4- yl)-5-(2-oxo-1-propyl-3-...)
Affinity DataIC50: 30nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527759(3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- t...)
Affinity DataIC50: 32nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 33nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527769(3-(1-methyl-1H-pyrazol-4- yl)-5-[2-oxo-1-(2,2,2- t...)
Affinity DataIC50: 37nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527767(5-[(3R)-4- (cyclopropylcarbonyl)-3-(2- methylpropy...)
Affinity DataIC50: 39nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527734(5-{1-[(3-methyloxetan-3- yl)methyl]-2-oxo-3-oxa-1,...)
Affinity DataIC50: 45nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527787(5-[(3R)-3-methyl-4- {[(1R,2R)-2- methylcyclopropyl...)
Affinity DataIC50: 50nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527773(5-(4-methyl-4-morpholin-4- ylpiperidin-1-yl)-3-(1-...)
Affinity DataIC50: 52nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527785(5-[(3R)-4-(azetidin-1- ylcarbonyl)-3- methylpipera...)
Affinity DataIC50: 53nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527760(5-[1-(cyclopropylmethyl)-2- oxo-3-oxa-1,8- diazasp...)
Affinity DataIC50: 54nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527755(5-[4-(cyclopropylmethyl)-2- oxo-3-oxa-1,8- diazasp...)
Affinity DataIC50: 55nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527756(5-(4-ethyl-3-oxo-2,8- diazaspiro[4.5]dec-8-yl)-3-(...)
Affinity DataIC50: 60nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527774(5-(4'-methyl-1,4'-bipiperidin- 1'-yl)-3-(1-methyl-...)
Affinity DataIC50: 70nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527765(3-[1-(difluoromethyl)-1H- pyrazol-4-yl]-5-[(3R)-3-...)
Affinity DataIC50: 73nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527775(5-{(3R)-4-[(cis-3- methoxycyclobutyl)carbonyl]- 3-...)
Affinity DataIC50: 100nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527776(5-{(3R)-4-[(3,3- difluorocyclobutyl)carbonyl]- 3-m...)
Affinity DataIC50: 100nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527783(5-[(3R)-4-{[(3S)-3- methoxypyrrolidin-1- yl]carbon...)
Affinity DataIC50: 110nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527778(5-[(3R)-3-methyl-4- propanoylpiperazin-1-yl]-3- (1...)
Affinity DataIC50: 150nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527784(5-{(3R)-4-[(3- methoxyazetidin-1- yl)carbonyl]-3- ...)
Affinity DataIC50: 160nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527780(3-(1-methyl-1H-pyrazol-4- yl)-5-[(3R)-3-methyl-4- ...)
Affinity DataIC50: 180nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50537740(CHEMBL4649678 | US11179389, Compound 1-13)
Affinity DataIC50: 190nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527782((2R)-4-[5-cyano-6-(1-methyl- 1H-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 210nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527786(methyl (2R)-4-[5-cyano-6-(1- methyl-1H-pyrazol-4- ...)
Affinity DataIC50: 210nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527779(5-{(3R)-3-methyl-4-[(1- methylcyclopropyl)carbonyl...)
Affinity DataIC50: 280nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527764((2R)-4-[5-cyano-6-(1-methyl- 1H-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 280nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM527781(5-[(3R)-3-methyl-4-(2-oxa-6- azaspiro[3.3]hept-6- ...)
Affinity DataIC50: 300nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In DepthDetails
US Patent