Compile Data Set for Download or QSAR
Report error Found 204 of ic50 data for polymerid = 10146
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50176071(2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-...)
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50121447(5-Nitro-furan-2-carboxylic acid N'-(2-naphthalen-2...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50352164(CHEMBL1824793)
Affinity DataIC50: 344nMAssay Description:Inhibition of human erythrocyte Glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50618202(CHEMBL5425052)
Affinity DataIC50: 590nMAssay Description:Inhibition of glutathione reductase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 750nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50051997(10-(4-Chloro-phenyl)-8-fluoro-3-methyl-10H-benzo[g...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052000(10-(3-Trifluoromethyl-phenyl)-10H-benzo[g]pteridin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052014(3-Methyl-10-(3-trifluoromethyl-phenyl)-10H-benzo[g...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50051998(3-Methyl-10-naphthalen-1-yl-10H-benzo[g]pteridine-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052004(3-Methyl-10-phenyl-10H-benzo[g]pteridine-2,4-dione...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052001(8-Azido-10-(4-chloro-phenyl)-3-methyl-10H-benzo[g]...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 2.70E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50051996(3-Methyl-10-pyridin-4-yl-10H-benzo[g]pteridine-2,4...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052007(10-(3,5-Bis-trifluoromethyl-phenyl)-10H-benzo[g]pt...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052006(10-Pentafluorophenyl-10H-benzo[g]pteridine-2,4-dio...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50051994(10-Anthracen-1-yl-3-methyl-10H-benzo[g]pteridine-2...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50096071(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052010(10-(3,5-Bis-trifluoromethyl-phenyl)-3-methyl-10H-b...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50177103(1-(2'-chlorophenyl)penta-1,4-dien-3-one | CHEMBL22...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human glutathione reductase after 5 mins pre-incubation with NADPH in presence of 500 uM GSSG substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50316592((2R(S),7R(S))-7-Hydroxybicyclo[2.2.1]heptan-2-yl n...)
Affinity DataIC50: 6.81E+3nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052013([10-(3,5-Dichloro-phenyl)-2,4-dioxo-4,10-dihydro-2...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293668((2S(R),7R(S))-7-Hydroxybicyclo[2.2.1]heptan-2-yl n...)
Affinity DataIC50: 7.13E+3nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293667((1R(S),2R(S),3S(R),4S(R))-2,3-Dihydroxycyclo-hexan...)
Affinity DataIC50: 7.17E+3nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50339129(Coruleoellagic acid | CHEMBL1688544)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human glutathione reductase by spectrophotometerMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052002(3-Methyl-10-pyridin-3-yl-10H-benzo[g]pteridine-2,4...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052011([2,4-Dioxo-10-(3-trifluoromethyl-phenyl)-4,10-dihy...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50015950(1,3-bis(2-chloroethyl)-1-nitrosourea | N,N'-Bis(2-...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human recombinant glutathione reductase using glutathione as substrate preincubated for 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293666((1S(R),3S(R),4S(R),6S(R))-4,6-Dihydroxycyclo-hexan...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293665((1R(S),2R(S),4R(S),5R(S))-2,5-Dihydroxycyclo-hexan...)
Affinity DataIC50: 8.71E+3nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM522150(US11161815, Example 6)
Affinity DataIC50: 8.76E+3nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM501861(US11028067, Example 2)
Affinity DataIC50: 9.89E+3nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50104661(Naphthalene-2-sulfonic acid [2-(6-chloro-2-methoxy...)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibitory concentration against human Glutathione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293664(9(R(S))-Hydroxy-1,2,3,4-tetrahydro-1,4-methano-nap...)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50293663((1S(R),2S(R),5R(S),6R(S))-5-Bromo-9-oxabicyclo[4.2...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM501863(US11028067, Example 4)
Affinity DataIC50: 1.12E+4nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052005([10-(4-Chloro-phenyl)-2,4-dioxo-4,10-dihydro-2H-be...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM94597((Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene...)
Affinity DataKi:  800nM ΔG°:  -34.8kJ/mole IC50: 1.20E+4nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50054332(3-Oxo-3,5-dihydro-2H-indeno[1,2-c]pyridazine-4-car...)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50352163(CHEMBL1824792)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of human erythrocyte Glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50104665(Naphthalene-2-sulfonic acid [4-(6-chloro-2-methoxy...)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibitory concentration against human Glutathione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutathione reductase, mitochondrial(Human)
Umr 8525 Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50052008([10-(3,5-Dichloro-phenyl)-2,4-dioxo-4,10-dihydro-2...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 uM GSSGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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