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Report error Found 47 of ic50 data for complexid = 50000720,50001452
LigandPNGBDBM50021809((2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-yliden...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
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PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50021812(2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 170nMAssay Description:Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid anti-corynanthine MIPs for Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
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LigandPNGBDBM50151930(3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-buty...)
Affinity DataIC50: 900nMAssay Description:Inhibition of Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228241(CHEMBL540511)
Affinity DataIC50: 1.00E+3nMAssay Description:Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228238(CHEMBL30911)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228237(CHEMBL554455)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005127(1,1-Dioxo-2-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-b...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 1.80E+3nMpH: 5.0Assay Description:Alpha-2 adrenergic receptor binding activity was determined by displacement of [3H]yohimbine in 50 mM phosphate buffer pH 5.0/Tween 20 where the poly...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50151946(3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226861(CHEMBL22073)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50036913(4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole | med...)
Affinity DataIC50: 2.90E+3nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)
Affinity DataIC50: 4.30E+3nMAssay Description:Antagonistic activity against Alpha-2 adrenergic receptor in human blood plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of alpha-2-adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50151935(5-Methoxy-3-{4-[4-(4-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226860(CHEMBL21734)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284689(CP-96486 | 7-Chloro-2-((E)-2-{3-[4-(2-methyl-imida...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50284690(CP-96021 | 1-(4-{3-[(E)-2-(5-Fluoro-benzothiazol-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50101815(CHEBI:7550 | Nicardipine)
Affinity DataIC50: 1.00E+4nMAssay Description:Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50005833(4-Amino-5-chloro-2-methoxy-N-(7a-methyl-hexahydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181839(N-exo-((4S,7alphaS)-tetrahydro-1H-pyrrolizin-4(5H)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181841((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1H-ind...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228239(CHEMBL2093965)
Affinity DataIC50: 1.00E+4nMAssay Description:Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181840((1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-Meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50470860(CHEMBL105328)
Affinity DataIC50: 1.43E+4nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50470864(CHEMBL420652)
Affinity DataIC50: 9.77E+4nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50228235(CHEMBL554235)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50228236(CHEMBL3350238)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 1.95E+5nMAssay Description:Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid where the polymer is anti-yohimbin MIPs for Alpha-2 adrenerg...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50027058((1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,1...)
Affinity DataIC50: 2.11E+5nMAssay Description:Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid anti-corynanthine MIPs for Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50470861(CHEMBL322844)
Affinity DataIC50: 2.15E+5nMAssay Description:Alpha-2 adrenergic receptor antagonistic activity in human blood platelets.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50027058((1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,1...)
Affinity DataIC50: 3.40E+5nMpH: 5.0Assay Description:Alpha-2 adrenergic receptor binding activity was determined displacement of [3H]-yohimbine in 50 mM phosphate buffer pH 5.0/Tween 20 where the polyme...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 3.98E+5nMpH: 5.0Assay Description:Compound was evaluated for the displacement of [3H]yohimbine in 50 mM phosphate buffer pH 5.0/Tween 20 where the polymer is anti-yohimbin MIPs for Al...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50027058((1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,1...)
Affinity DataIC50: 8.71E+5nMpH: 5.0Assay Description:Compound was evaluated for the displacement of [3H]yohimbine in 50 mM phosphate buffer pH 5.0/Tween 20 where the polymer is anti-yohimbin MIPs for Al...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50027058((1S,2S,4aR,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,1...)
Affinity DataIC50: 1.04E+6nMAssay Description:Compound was evaluated for the displacement of [3H]yohimbine in acetonitrile/acetic acid where the polymer is anti-yohimbin MIPs for Alpha-2 adrenerg...More data for this Ligand-Target Pair
In DepthDetails