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TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569838(Tinostamustine | EDO-S 101 | EDO-S-101 | EDO-S101)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC class1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 22nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 34nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50462732(CHEMBL4248676)
Affinity DataIC50: 100nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50: 120nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50: 160nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 189nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522146(CHEMBL4469317)
Affinity DataIC50: 195nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50: 200nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522150(CHEMBL4466520)
Affinity DataIC50: 235nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 240nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551543(CHEMBL4757035)
Affinity DataIC50: 250nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522151(CHEMBL4571280)
Affinity DataIC50: 258nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522148(CHEMBL4454331)
Affinity DataIC50: 278nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522145(CHEMBL4463774)
Affinity DataIC50: 292nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522149(CHEMBL4516302)
Affinity DataIC50: 296nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50: 300nMAssay Description:Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569641(CHEMBL4872186)
Affinity DataIC50: 300nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 350nMAssay Description:Inhibition of class 1 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC addition and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522142(CHEMBL566831)
Affinity DataIC50: 370nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522144(CHEMBL4466864)
Affinity DataIC50: 371nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522143(CHEMBL4518387)
Affinity DataIC50: 415nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50522147(CHEMBL4573804)
Affinity DataIC50: 420nMAssay Description:Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 470nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551540(CHEMBL4762873)
Affinity DataIC50: 550nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569630(CHEMBL4873847)
Affinity DataIC50: 590nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551535(CHEMBL4752558)
Affinity DataIC50: 600nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 620nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551539(CHEMBL4751082)
Affinity DataIC50: 670nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50: 710nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551536(CHEMBL4750838)
Affinity DataIC50: 800nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551537(CHEMBL4753795)
Affinity DataIC50: 810nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50511599(CHEMBL4576202)
Affinity DataIC50: 860nMAssay Description:Inhibition of class 1 HDAC n human HeLa cell nuclear extracts pre-incubated for 5 mins before fluorogenic substrate Boc-Lys (acetyl)-AMC addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569639(CHEMBL4858081)
Affinity DataIC50: 860nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569642(CHEMBL4879154)
Affinity DataIC50: 880nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 950nMAssay Description:Inhibition of HDAC class 1 in human HT-29 cells using Boc-Lys-Ac as substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50258579((S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50509450(CHEMBL4474656)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 0.5 uM prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569643(CHEMBL4867665)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50509442(CHEMBL4564332)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 5 uM preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50509443(CHEMBL4587363)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 3.2 uM prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of class 1 HDAC in human CAL27 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 0.5 uM prei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50602709(CHEMBL5175492)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC class 1 in human HT-29 cells using Boc-Lys-Ac as substrate incubated for 3 hrs by microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50551541(CHEMBL4757768)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569640(CHEMBL4861270)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50569642(CHEMBL4879154)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of class 1 HDAC in quiescent human primary T-cell model of VSV-G pseudotyped HIV-1 latency assessed as reactivation of HIV latency incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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