Compile Data Set for Download or QSAR
Report error Found 3663 Enz. Inhib. hit(s) with BLAST sequence identity > 85%
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007674((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)
Affinity DataKd:  94nMAssay Description:Binding affinity towards human NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50203305(benzyl 4-[(pyridin-4-ylamino)methyl]piperidine-1-c...)
Affinity DataEC50:  1.60nMAssay Description:Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50203311(4-methylbenzyl 4-[(2-pyrimidinylamino)methyl]-1-pi...)
Affinity DataEC50:  5.60nMAssay Description:Antagonist activity at human NR2B expressed in Ltk- cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards human NR2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385168(CHEMBL2036514)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385169(CHEMBL2036513)
Affinity DataKd:  15.2nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain thalamusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385168(CHEMBL2036514)
Affinity DataKd:  5.40nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain thalamusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385169(CHEMBL2036513)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain olfactory tubercleMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385168(CHEMBL2036514)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain olfactory tubercleMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385169(CHEMBL2036513)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385169(CHEMBL2036513)
Affinity DataKd:  9.80nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385168(CHEMBL2036514)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385169(CHEMBL2036513)
Affinity DataKd:  9.10nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain hippocampusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM50385168(CHEMBL2036514)
Affinity DataKd:  7.10nMAssay Description:Binding affinity to NMDAR NR2B in Sprague-Dawley rat brain hippocampusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM79403(N,N''-bis(3-azanylpropyl)butane-1,4-diamine;hydroc...)
Affinity DataEC50:  1.27E+5nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic(Rat)
Institute of Biomedical Imaging (I2Bm)

Curated by ChEMBL
LigandPNGBDBM79403(N,N''-bis(3-azanylpropyl)butane-1,4-diamine;hydroc...)
Affinity DataEC50:  8.10E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor in rat spinal cord neurons assessed as increase in glycine-induced channel current by two electrode...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM79403(N,N''-bis(3-azanylpropyl)butane-1,4-diamine;hydroc...)
Affinity DataEC50:  1.25E+5nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) in hippocampal neurons assessed as increase in glycine-induced channel current by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataEC50:  3.30E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50503152(CHEMBL4452216)
Affinity DataEC50:  3.40E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50503147(CHEMBL4435232)
Affinity DataEC50:  1.57E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50503144(CHEBI:35420 | CHEMBL1179605)
Affinity DataEC50:  6.30E+4nMAssay Description:Positive allosteric modulation of EGFP-fused human GluN2B receptor expressed in HEK293T cells assessed as increase in glycine-induced channel current...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50436060(CHEMBL2397100 | US10273214, Example 1390)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of GluN2B receptor (unknown origin) expressed in xenopus laevis oocytes assessed as increase in glycine-induced channe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007674((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes incubated for 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521554(US11149054, Compound 1839)
Affinity DataEC50:  148nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521558(US11149054, Compound 1)
Affinity DataEC50:  70.9nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521559(US11149054, Compound 2)
Affinity DataEC50:  147nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521560(US11149054, Compound 2A)
Affinity DataEC50:  339nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521561(US11149054, Compound 2B)
Affinity DataEC50:  143nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521562(US11149054, Compound 10)
Affinity DataEC50:  102nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521563(US11149054, Compound 1-A)
Affinity DataEC50:  81.2nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521564(US11149054, Compound 1-B)
Affinity DataEC50:  33.6nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521565(US11149054, Compound 7)
Affinity DataEC50:  287nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521566(US11149054, Compound 9)
Affinity DataEC50:  234nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521567(US11149054, Compound 3)
Affinity DataEC50:  338nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521568(US11149054, Compound 1967)
Affinity DataEC50:  113nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521569(US11149054, Compound 7-B)
Affinity DataEC50:  306nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521570(US11149054, Compound 7-A)
Affinity DataEC50:  187nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521571(US11149054, Compound 8)
Affinity DataEC50:  372nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521572(US11149054, Compound 4)
Affinity DataEC50:  212nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521573(US11149054, Compound 5)
Affinity DataEC50:  260nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521574(US11149054, Compound 6)
Affinity DataEC50:  733nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521575(US11149054, Compound 11)
Affinity DataEC50:  104nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521576(US11149054, Compound 2080)
Affinity DataEC50:  187nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521577(US11149054, Compound 2081)
Affinity DataEC50:  175nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521578(US11149054, Compound 2184)
Affinity DataEC50:  80nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521579(US11149054, Compound 2285)
Affinity DataEC50:  494nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521580(US11149054, Compound 2392)
Affinity DataEC50:  47.5nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521581(US11149054, Compound 2499)
Affinity DataEC50:  751nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521582(US11149054, Compound 2500)
Affinity DataEC50:  91.1nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B NMDA 2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM521583(US11149054, Compound 2602)
Affinity DataEC50:  279nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of positive allosteric modulating activity of test compounds on GlunN1/GluN2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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