Release Notes for 2025-09-30: Number of new affinity data: 19644 Number of compounds (ligands) new to BindingDB: 10407 Number of Targets new to BindingDB: 17 New Targets: Fibroblast growth factor receptor 2 [V564F] (P21802[V546F]): 56 inhibitors GTPase KRas [G12C]/Serine/threonine-protein kinase B-raf (P01116[G12C],P15056): 11 inhibitors Histone-lysine N-methyltransferase NSD2 [2-1365] (O96028[2-1365]): 20 inhibitors Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [339-715] (Q9UDY8[339-715]): 67 inhibitors Myosin-binding protein C, cardiac-type (Q14896): 1 inhibitors Nuclear receptor subfamily 2 group E member 1/Nuclear receptor-interacting protein 1 (P48552): 25 inhibitors Receptor-type tyrosine-protein phosphatase N2 [1-387] (Q92932[1-387]): 13 inhibitors Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] (P10398[273-606,Y301D,Y302D]): 499 inhibitors Serine/threonine-protein kinase B-raf [416-766] (P15056[416-766]): 499 inhibitors Serine/threonine-protein kinase ULK1 [1-649] (O75385[1-649]): 252 inhibitors Sodium-dependent neutral amino acid transporter B(0)AT1 (Q695T7): 213 inhibitors Stromelysin-1 (MMP3) (P08254): 4 inhibitors TBD (unmapped): 1 inhibitors UDP-glucose 6-dehydrogenase (O60701): 28 inhibitors irak4 (unmapped): 80 inhibitors kras g12d coupled exchange (Q07889[564-1049],P01116[1-169,G12D]): 71 inhibitors kras g12d tr-fret (P01116[G12D]): 71 inhibitors Number of new Entries: 96 PubMed id or Patent id Title US12291516 Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors US12291519 2-hydroxycycloalkane-1-carbamoyl US12291534 Aminonorbornane derivative and manufacture method therefor and use thereof US12297164 Benzidine compound and application thereof US12297186 Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor I/ALK5 US12297203 Pyrrolopyrimidine ITK inhibitors US12303509 Compounds for the treatment of BRAF-associated diseases and disorders US12303512 Therapeutically active compounds and their methods of use US12304894 Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1) US12304897 15-PGDH inhibitors US12304898 Quinolyl-containing compound and pharmaceutical composition, and use thereof US12304901 Selective ligands for tau aggregates US12304914 Pyrazolo[3,4-d]pyrrolo[1,2-b]pyridazinyl compounds useful as IRAK4 inhibitors US12304916 Thienopyridinyl and thiazolopyridinyl compounds useful as IRAK4 inhibitors US12310975 Modulators of BCL6 proteolysis and associated methods of use US12312329 Aminopyrimidine compound used for inhibiting activity of protein kinase US12312355 1H-[1, 2, 3]triazolo[4, 5-h] quinazoline compounds acting as protein kinase inhibitors US12318398 MST1 kinase inhibitor and use thereof US12319655 RAF kinase inhibitors and methods of use thereof US12319671 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof US12319672 Alpha-D-galactopyranoside derivatives US20250134842 FATTY ACID MIMETICS AS MODULATORS OF NUCLEAR RECEPTOR TLX (NR2E1) US20250134869 Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides US20250134882 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF US20250136553 ACYLSULFONAMIDE KAT6A INHIBITORS US20250136564 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF US20250136570 HDAC INHIBITORS AND THERAPEUTIC USE THEREOF US20250136577 HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS US20250136581 SUBSTITUTED TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF US20250136586 Substituted 7-(Pyrimidin-4-yl)Quinolin-4(1H)-One Compounds as Cyclin Dependent Kinase Inhibitors US20250136592 C-LINKED INHIBITORS OF ENL/AF9 YEATS US20250136596 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF US20250136601 CYCLOPIPERIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF US20250136608 COMPOUNDS CONTAINING A GEM-DIFLUORIDE GROUP AND PREPARATION METHOD AND USE THEREOF US20250136618 ANTIBIOTIC PYRAZINOTHIAZINE DERIVATIVES AND PROCESS OF PREPARATION THEREOF US20250136619 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE US20250136638 9(11)-UNSATURATED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE US20250144094 THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF US20250144172 ANTI-FIBROTIC SIALIDASE INHIBITOR COMPOUNDS AND METHODS OF USE US20250145565 DITHIENYL DISULFIRAM DERIVATIVES AS SELECTIVE ALDH1A1 INHIBITORS US20250145576 CATHEPSIN K INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF US20250145589 PYRIDINE DERIVATIVE AND USE THEREOF US20250145606 THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF US20250145619 KHK INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF US20250145624 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF US20250145625 PYRAZOLOPYRIMIDINE DERIVATIVE AND ANTICANCER PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT US20250145632 Pyrimidine Heterocyclic Compound, Preparation Method Thereof and use Thereof in Medicine US20250145633 SUBSTITUTED FURANOPYRIMIDINE COMPOUNDS AS PDE1 INHIBITORS US20250145635 COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE US20250145637 SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF US20250145642 BICYCLIC HETEROARENES AND METHODS OF THEIR USE US20250152564 PROPYLENE KETONE-CONTAINING BIOINHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF US20250152719 FUSED IMIDE DERIVATIVE US20250154108 CRYSTAL FORM OF 7-AZASPIRO[4,5]DECANE-6,10-DIONE COMPOUND AND PREPARATION METHOD THEREFOR US20250154115 ARYLBENZOISOXAZOLE COMPOUNDS AS IP6K AND IPMK INHIBITORS AND METHODS OF USE THEREOF US20250154131 PYRROLIDINE ANTIVIRAL COMPOUND US20250154134 COMPOUND AS FAK INHIBITOR AND USE THEREOF US20250154138 Small Molecule IL-17A Modulators US20250154139 PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS US20250154147 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS US20250154150 SUBSTITUTED FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USES THEREOF US20250154153 DIHYDROIMIDAZO-PYRIMIDINONE COMPOUNDS AS LP-PLA2 INHIBITORS AND USE THEREOF US20250154162 COMPOUND FOR REGULATING AND CONTROLLING 15-PGDH ACTIVITY AND PREPARATION METHOD THEREFOR US20250161307 PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE US20250161319 USE OF HPK1 INHIBITOR IN TREATMENT OF INTERFERON-RELATED DISEASES US20250161321 AMINO ACID BASED CARBAMATES AND/OR UREAS FOR THE TREATMENT OF SORTILIN DEPENDENT DISEASES US20250161476 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF US20250162989 USP30 INHIBITORS AND USES THEREOF US20250162994 DUAL LSD1/HDAC INHIBITORS US20250163036 DIPEPTIDYL PEPTIDASE 1 INHIBITOR POLYMORPH, PREPARATION METHOD AND USE THEREFOR US20250163056 NONMUSCLE MYOSIN II INHIBITORS US20250163057 DCN-1 MODULATING COMPOUNDS AND METHODS OF USE THEREOF US20250163061 INHIBITORS OF MENIN-MLL INTERACTION US20250163063 INHIBITORS OF CDK4/6 KINASE US20250163064 QUINAZOLINE COMPOUNDS AND USES THEREOF AS INHIBITORS OF MUTANT KRAS PROTEINS US20250163065 PYRROLOTRIAZINONE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF US20250163066 PROTACs of MALT1 US20250163067 NUCLEOBASE-SUBSTITUTED PIPERIDINYL-PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING DISEASES AND CONDITIONS US20250163068 COMPOUNDS AND THEIR METHODS OF USE US20250163070 SPIRO COMPOUND AND APPLICATION THEREOF US20250163072 MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER US20250163074 CDK Inhibitors And Their Use As Pharmaceuticals US20250163075 HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS US20250163077 MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (PKMYT1) INHIBITORS AND USES THEREOF US20250170100 MONOACYLGLYCEROL LIPASE INHIBITORS AND USE THEREOF FOR THE TREATMENT OF ANXIETY AND RELATED CONDITIONS US20250170104 INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR Lasß US20250170122 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS US20250170126 NOVEL B0AT1 INHIBITOR US20250170136 1,2,4-TRIAZIN-3(2H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES US20250171400 AZA-HETEROCYCLYL CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS US20250171414 COMPOUND SERVING AS MASP-2 INHIBITOR, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF US20250171431 HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE US20250171447 ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE THEREOF US20250171452 TRYPTANTHRIN DERIVATIVES AND USES THEREOF US20250171454 HETEROBIFUNCTIONAL PYRIDINYLMETHYL AMINOPURINE AND RELATED COMPOUNDS AND THEIR USE IN NSD2 DEGRADATION AND TREATING MEDICAL CONDITIONS US20250171467 FUSED PYRAZOLE AMIDE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS