BDBM50565138 CHEMBL595227::PD-404182

SMILES N=C1Sc2ccccc2C2=NCCCN12

InChI Key InChIKey=JNENSSREQFBZGT-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50565138   

TargetHistone deacetylase 1(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human HDAC1 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human HDAC2 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human HDAC3 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human HDAC6 using Boc-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human HDAC4 using Boc-Lys(tri-fluoracetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC8 using Boc-Lys(tri-fluoracetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 110nMAssay Description:Inhibition of human HDAC5 using Boc-Lys(tri-fluoracetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 220nMAssay Description:Inhibition of human HDAC7 using Boc-Lys(tri-fluoracetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human DDAH1 using SMTC as substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of human DDAH1 expressed using SMTC as substrate assessed as inhibition constant measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50565138(PD-404182 | CHEMBL595227)
Affinity DataKi: >1.90E+6nMAssay Description:Inhibition of human nNOS assessed as inhibition constant measured after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed